Interactor 1: CCND1 (P24385)
G1/S-specific cyclin-D1 (B-cell lymphoma 1 protein) (BCL-1) (BCL-1 oncogene) (PRAD1 oncogene)
Gene: CCND1
Interactor 2: CDK2 (P24941)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
Gene: CDK2
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.96 | 1.00 | 0.981 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 28514442, 21654808, 33854235, 33961781, 33854239, 23737759, 9178893, 26496610, 8647086, 23455922, 8479754, 34591642, 9840943 |
| Identification Methods | affinity chromatography technology, pull down, coimmunoprecipitation, anti tag coimmunoprecipitation, two hybrid, tandem affinity purification |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Cyclin_C~Pkinase, Cyclin_N~Pkinase |
| Common GO terms | GO:0000082 - G1/S transition of mitotic cell cycle GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0005634 - nucleus GO:0005654 - nucleoplasm and 5 others more... |
| Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
