HitPredict

Interactor 1: CCND1 (P24385)
G1/S-specific cyclin-D1 (B-cell lymphoma 1 protein) (BCL-1) (BCL-1 oncogene) (PRAD1 oncogene)
Gene: CCND1

Interactor 2: CDN1A (P38936)
Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21)
Gene: CDKN1A

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.992

The method score is based on:

Property Details
Experiments 25416956, 26203195, 23007395, 28514442, 9823309, 21654808, 33854235, 8657154, 23737759, 15695403, 17556661, 8756624, 15232106, 21988832, 21516116, 27107012, 30833792, 33961781, 16082198, 12383116 and 6 others

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Identification Methods two hybrid, affinity chromatography technology, pull down, coimmunoprecipitation, two hybrid prey pooling approach, two hybrid array, validated two hybrid, barcode fusion genetics two hybrid, protein array, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains CDI~Cyclin_N
Common GO terms GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000307 - cyclin-dependent protein kinase holoenzyme complex
GO:0001934 - positive regulation of protein phosphorylation
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
and 4 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 295
Hs

1 164
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Last updated: 15 Jul 2024