HitPredict

Interactor 1: IL4RA (P24394)
Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)]
Gene: IL4R

Interactor 2: PTN11 (Q06124)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Gene: PTPN11

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	11714803
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0019221 - cytokine-mediated signaling pathway
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 825 Hs			1 593
+	Hs
		622722 IL4RA_HUMAN (1-825): 4.27e-169: 512: 100.00		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		560475 PRLR_HUMAN (32-541): 1.79e-68: 240: 14.26		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		701713 IL3RB_HUMAN (29-730): 7.63e-59: 218: 20.25		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		665805 IL3RB_HUMAN (29-730): 7.63e-59: 218: 20.25		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		770199 IL6RB_HUMAN (18-228): 2.34e-42: 168: 18.10		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		540446 IL2RB_HUMAN (22-553): 3.49e-60: 215: 15.92		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		581161 EPOR_HUMAN (21-477): 5.52e-43: 165: 16.74		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Mm
		719297 IL6RB_MOUSE (18-228): 2.39e-28: 124: 17.20		PTN11_MOUSE (1-593): 0: 580: 99.49
+	Hs
		665811 IL6RB_HUMAN (18-228): 2.34e-42: 168: 18.10		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		581151 EPOR_HUMAN (21-477): 5.52e-43: 165: 16.74		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Mm
		562609 GHR_MOUSE (33-286): 1.26e-22: 105: 15.19		PTN11_MOUSE (1-593): 0: 580: 99.49
+	Hs
		1031984 I13R2_HUMAN (28-267): 4.85e-61: 213: 18.40		PTPRS_HUMAN (39-522): 8.52e-117: 384: 26.76
+	Hs
		616945 IL2RG_HUMAN (23-342): 8.09e-60: 209: 17.42		PTPRD_HUMAN (39-522): 2.1e-115: 379: 26.76
+	Hs
		489962 I13R2_HUMAN (28-267): 4.85e-61: 213: 18.40		PTPRF_HUMAN (33-522): 2.6e-112: 371: 25.85
+	Hs
		581148 EPOR_HUMAN (21-477): 5.52e-43: 165: 16.74		PTPRB_HUMAN (147-555): 2.35e-115: 379: 27.91
+	Hs
		581162 EPOR_HUMAN (21-477): 5.52e-43: 165: 16.74		PTPRJ_HUMAN (146-528): 1.52e-109: 359: 30.55
+	Hs
		573561 EPOR_HUMAN (21-477): 5.52e-43: 165: 16.74		PTN1_HUMAN (232-541): 4.38e-110: 338: 31.63
+	Hs
		441174 EPOR_HUMAN (21-477): 5.52e-43: 165: 16.74		PTPRC_HUMAN (33-579): 2.25e-85: 291: 18.29
+	Hs
		581149 EPOR_HUMAN (21-477): 5.52e-43: 165: 16.74		PTPRG_HUMAN (33-527): 9.52e-62: 223: 17.05