HitPredict

Interactor 1: GA45A (P24522)
Growth arrest and DNA damage-inducible protein GADD45 alpha (DNA damage-inducible transcript 1 protein) (DDIT-1)
Gene: GADD45A

Interactor 2: M3K4 (Q9Y6R4)
Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAP three kinase 1) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4)
Gene: MAP3K4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.636

Property	Details
Experiments	9827804, 33961781
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:1900745 - positive regulation of p38MAPK cascade
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 165 Hs			1 1608
+	Hs
		258882 GA45B_HUMAN (1-165): 6.18e-79: 233: 55.76		M3K4_HUMAN (1-1608): 0: 2122: 100.00
+	Hs
		309892 GA45G_HUMAN (1-164): 7.43e-73: 217: 54.49		M3K4_HUMAN (1-1608): 0: 2122: 100.00