Interactor 1: CCNC (P24863)
Cyclin-C (SRB11 homolog) (hSRB11)
Gene: CCNC

Interactor 2: CDK8 (P49336)
Cyclin-dependent kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 8) (Mediator complex subunit CDK8) (Mediator of RNA polymerase II transcription subunit CDK8) (Protein kinase K35)
Gene: CDK8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.992

The method score is based on:

Property Details
Experiments 25416956, 26186194, 28514442, 29997244, 30695077, 33961781, 26496610, 29568061, 9150135, 11416138, 24981860, 11867769, 7568034, 32707033, 10024883, 10882111, 10353252, 15328539, 23602568, 26502155 and 6 others

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Identification Methods two hybrid, affinity chromatography technology, fluorescent resonance energy transfer, proximity labelling technology, pull down, biochemical, x-ray crystallography, molecular sieving, anti bait coimmunoprecipitation, two hybrid prey pooling approach and 5 others

more...

Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Cyclin_C_2~Pkinase, Cyclin_N~Pkinase
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0016592 - mediator complex
GO:1990508 - CKM complex
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 283
Hs

1 464
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Last updated: 15 Jul 2024