Interactor 1: CCNC (P24863)
Cyclin-C (SRB11 homolog) (hSRB11)
Gene: CCNC
Interactor 2: CDK8 (P49336)
Cyclin-dependent kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 8) (Mediator complex subunit CDK8) (Mediator of RNA polymerase II transcription subunit CDK8) (Protein kinase K35)
Gene: CDK8
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
Method score | Annotation score | Interaction score |
---|---|---|
0.98 | 1.00 | 0.992 |
The method score is based on:
Property | Details |
---|---|
Experiments | 25416956, 26186194, 28514442, 29997244, 30695077, 33961781, 26496610, 29568061, 9150135, 11416138, 24981860, 11867769, 7568034, 32707033, 10024883, 10882111, 10353252, 15328539, 23602568, 26502155 and 6 others
more... |
Identification Methods | two hybrid, affinity chromatography technology, fluorescent resonance energy transfer, proximity labelling technology, pull down, biochemical, x-ray crystallography, molecular sieving, anti bait coimmunoprecipitation, two hybrid prey pooling approach and 5 others
more... |
Interaction Type | direct interaction, physical association, association |
The annotation score is based on:
Property | Details |
---|---|
Interacting Pfam domains | Cyclin_C_2~Pkinase, Cyclin_N~Pkinase |
Common GO terms | GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016592 - mediator complex GO:1990508 - CKM complex |
Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores
Service provided by Combinatics, Japan
Last updated: 15 Jul 2024