HitPredict

Interactor 1: CCNC (P24863)
Cyclin-C (SRB11 homolog) (hSRB11)
Gene: CCNC

Interactor 2: CDK3 (Q00526)
Cyclin-dependent kinase 3 (EC 2.7.11.22) (Cell division protein kinase 3)
Gene: CDK3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.894

Property	Details
Experiments	32296183, 15084261, 25344755, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, anti bait coimmunoprecipitation, validated two hybrid, two hybrid array, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Cyclin_C_2~Pkinase, Cyclin_N~Pkinase
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0005634 - nucleus GO:0045023 - G0 to G1 transition GO:0045746 - negative regulation of Notch signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 283 Hs			1 305
+	Hs
		538521 CCNB1_HUMAN (1-276): 2.06e-79: 248: 14.95		CDK3_HUMAN (1-305): 1.8e-151: 427: 100.00
+	Hs
		538471 CCNB1_HUMAN (1-276): 2.06e-79: 248: 14.95		CDK2_HUMAN (1-292): 1.87e-148: 420: 76.71
+	Hs
		625350 CCNA1_HUMAN (2-270): 1.81e-75: 239: 17.46		CDK2_HUMAN (1-292): 1.87e-148: 420: 76.71
+	Mm
		956332 CCNC_MOUSE (1-283): 9.53e-80: 244: 99.29		CDK2_MOUSE (1-292): 1.46e-139: 399: 65.88
+	Hs
		414711 CCNB1_HUMAN (1-276): 2.06e-79: 248: 14.95		CDK1_HUMAN (1-290): 1.16e-137: 392: 65.98
+	Mm
		956329 CCNA1_MOUSE (10-270): 4.05e-75: 237: 17.23		CDK2_MOUSE (1-292): 1.46e-139: 399: 65.88
+	Mm
		509487 CCNC_MOUSE (1-283): 9.53e-80: 244: 99.29		CDK1_MOUSE (1-290): 1.15e-136: 390: 66.32
+	Mm
		509465 CCNB1_MOUSE (1-276): 3.22e-77: 242: 14.24		CDK1_MOUSE (1-290): 1.15e-136: 390: 66.32
+	Hs
		414855 CCNA1_HUMAN (2-270): 1.81e-75: 239: 17.46		CDK1_HUMAN (1-290): 1.16e-137: 392: 65.98
+	At
		621689 CCA32_ARATH (1-267): 4.47e-76: 237: 10.83		CDKA1_ARATH (1-293): 1.36e-137: 392: 68.03
+	Hs
		538522 CCNB1_HUMAN (1-276): 2.06e-79: 248: 14.95		CDK5_HUMAN (1-292): 8.97e-133: 380: 60.75
+	Hs
		303821 CCNB2_HUMAN (1-269): 6.39e-75: 235: 13.87		CDK1_HUMAN (1-290): 1.16e-137: 392: 65.98
+	Hs
		624423 CCNC_HUMAN (1-283): 1.05e-79: 244: 100.00		CDK5_HUMAN (1-292): 8.97e-133: 380: 60.75
+	At
		1247203 CCL11_ARATH (14-244): 8.17e-75: 236: 27.20		Q9CAG1_ARATH (1-305): 7.05e-128: 383: 45.08
+	Hs
		277494 CCNK_HUMAN (14-259): 3.82e-73: 236: 26.52		CDK5_HUMAN (1-292): 8.97e-133: 380: 60.75
+	At
		1319943 CCA32_ARATH (1-267): 4.47e-76: 237: 10.83		CDKD1_ARATH (2-302): 2.64e-128: 372: 46.84
+	Sp
		251722 CG1C_SCHPO (8-279): 1.86e-76: 238: 28.57		CDK1_SCHPO (1-288): 1.98e-129: 371: 63.05
+	At
		1106926 CCB13_ARATH (2-272): 5.83e-76: 239: 13.00		CDKD2_ARATH (1-302): 9.62e-128: 369: 48.01
+	Hs
		538497 CCNB1_HUMAN (1-276): 2.06e-79: 248: 14.95		CDK7_HUMAN (3-296): 2.86e-124: 360: 45.64
+	Hs
		277495 CCNK_HUMAN (14-259): 3.82e-73: 236: 26.52		CDK16_HUMAN (1-288): 4.21e-108: 324: 54.33