HitPredict

Interactor 1: CCNE1 (P24864)
G1/S-specific cyclin-E1
Gene: CCNE1

Interactor 2: CDN1B (P46527)
Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1)
Gene: CDKN1B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.98	1.00	0.991

Property	Details
Experiments	27175940, 24632684, 33961781, 12529437, 25483085, 34591612, 8891332, 9311993, 11940657, 17254967, 9891079, 31822694, 14691455, 17293600, 20837141, 10393546, 9716181, 9632134, 9218599, 9192873 and 5 others more... 8978686, 8756624, 9660939, 19470470, 17254966
Identification Methods	affinity chromatography technology, pull down, enzymatic study, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	CDI~Cyclin_N
Common GO terms	GO:0000082 - G1/S transition of mitotic cell cycle GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol and 1 others more... GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 410 Hs			1 198
+	Mm
		803843 CCNE1_MOUSE (1-408): 5.19e-120: 356: 78.97		CDN1B_MOUSE (1-197): 4.44e-75: 225: 87.31
+	Hs
		624557 CCNE1_HUMAN (1-410): 2.36e-135: 395: 100.00		CDN1A_HUMAN (17-167): 1.06e-46: 152: 27.10
+	Hs
		590142 CCNA2_HUMAN (2-369): 1.62e-99: 304: 20.58		CDN1B_HUMAN (1-198): 1.46e-79: 237: 100.00
+	Hs
		331632 CCNE2_HUMAN (4-402): 7.36e-97: 297: 47.38		CDN1B_HUMAN (1-198): 1.46e-79: 237: 100.00
+	Hs
		804103 CCNA1_HUMAN (15-367): 4.41e-96: 297: 20.98		CDN1B_HUMAN (1-198): 1.46e-79: 237: 100.00
+	Hs
		303836 CCNB2_HUMAN (8-365): 2.69e-96: 295: 19.57		CDN1B_HUMAN (1-198): 1.46e-79: 237: 100.00
+	Mm
		803837 CCNA2_MOUSE (3-367): 2.41e-100: 306: 21.33		CDN1B_MOUSE (1-197): 4.44e-75: 225: 87.31
+	Xl
		841954 CCNE1_XENLA (7-406): 2.12e-121: 359: 59.95		Q91646_XENLA (14-190): 2.49e-51: 166: 26.00
+	Xl
		193814 CCNE3_XENLA (7-407): 5.24e-120: 356: 58.81		Q91646_XENLA (14-190): 2.49e-51: 166: 26.00
+	Xl
		841953 CCNE1_XENLA (7-406): 2.12e-121: 359: 59.95		Q5V9L9_XENLA (19-166): 4.75e-37: 127: 26.35
+	Hs
		87258 C9J2U0_HUMAN (16-410): 3.02e-112: 334: 88.61		CDN1A_HUMAN (17-167): 1.06e-46: 152: 27.10
+	Hs
		590139 CCNA2_HUMAN (2-369): 1.62e-99: 304: 20.58		CDN1A_HUMAN (17-167): 1.06e-46: 152: 27.10
+	Mm
		763418 CCNA1_MOUSE (4-369): 2.9e-97: 298: 20.59		CDN1A_MOUSE (17-167): 3.27e-48: 156: 27.27
+	Hs
		331630 CCNE2_HUMAN (4-402): 7.36e-97: 297: 47.38		CDN1A_HUMAN (17-167): 1.06e-46: 152: 27.10
+	Hs
		758186 CCNA1_HUMAN (15-367): 4.41e-96: 297: 20.98		CDN1A_HUMAN (17-167): 1.06e-46: 152: 27.10
+	Hs
		303835 CCNB2_HUMAN (8-365): 2.69e-96: 295: 19.57		CDN1A_HUMAN (17-167): 1.06e-46: 152: 27.10
+	Hs
		538489 CCNB1_HUMAN (1-365): 5.55e-95: 293: 18.82		CDN1A_HUMAN (17-167): 1.06e-46: 152: 27.10
+	Hs
		590146 CCNA2_HUMAN (2-369): 1.62e-99: 304: 20.58		CDN1C_HUMAN (1-123): 4.27e-27: 106: 35.42
+	Hs
		331633 CCNE2_HUMAN (4-402): 7.36e-97: 297: 47.38		CDN1C_HUMAN (1-123): 4.27e-27: 106: 35.42
+	Hs
		303838 CCNB2_HUMAN (8-365): 2.69e-96: 295: 19.57		CDN1C_HUMAN (1-123): 4.27e-27: 106: 35.42