HitPredict

Interactor 1: CCNE1 (P24864)
G1/S-specific cyclin-E1
Gene: CCNE1

Interactor 2: FOXM1 (Q08050)
Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HFH-11) (HNF-3/fork-head homolog 11) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident) (Winged-helix factor from INS-1 cells)
Gene: FOXM1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	15024056, 16504183
Identification Methods	affinity chromatography technology, enzymatic study, pull down, protein kinase assay
Interaction Type	physical association, direct interaction, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0019901 - protein kinase binding
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 410 Hs			1 763
+	Hs
		538528 CCNB1_HUMAN (1-365): 5.55e-95: 293: 18.82		FOXM1_HUMAN (1-763): 0: 1022: 100.00
+	Dm
		593422 CCNB_DROME (4-365): 5.7e-86: 273: 18.90		FD3_DROME (191-372): 2.81e-47: 176: 26.49