Interactor 1: RPB1 (P24928)
DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)
Gene: POLR2A

Interactor 2: CDK8 (P49336)
Cyclin-dependent kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 8) (Mediator complex subunit CDK8) (Mediator of RNA polymerase II transcription subunit CDK8) (Protein kinase K35)
Gene: CDK8

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.88 0.60 0.727

The method score is based on:

Property Details
Experiments 24981860, 15328539, 22379099, 9710619, 15009212, 11278802
Identification Methods affinity chromatography technology, enzymatic study
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
Homologous interactions 11

Homologous interactions

Color coding for hit scores

1 1970
Hs

1 464
+ Hs
+ Hs
+ At
+ At
+ At
+ Sc
+ Sc
+ Zm
+ Zm
+ Dm
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024