HitPredict

Interactor 1: RPB1 (P24928)
DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)
Gene: POLR2A

Interactor 2: SMCA2 (P51531)
Probable global transcription activator SNF2L2 (EC 3.6.4.-) (ATP-dependent helicase SMARCA2) (BRG1-associated factor 190B) (BAF190B) (Protein brahma homolog) (hBRM) (SNF2-alpha) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2)
Gene: SMARCA2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.552

Property	Details
Experiments	11238380, 8895581
Identification Methods	biochemical
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006355 - regulation of DNA-templated transcription GO:0016787 - hydrolase activity
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1970 Hs			1 1590
+	Mm
		444961 RPB1_MOUSE (1-1611): 0: 1858: 100.00		SMCA4_MOUSE (40-1588): 0: 986: 72.81
+	Hs
		624816 RPB1_HUMAN (1-1611): 0: 1858: 100.00		SMCA4_HUMAN (40-1588): 0: 977: 72.70
+	Hs
		625053 RPB1_HUMAN (1-1611): 0: 1858: 100.00		CHD8_HUMAN (19-1359): 0: 741: 21.67
+	Sc
		375326 RPB1_YEAST (11-1592): 0: 1458: 48.49		STH1_YEAST (1216-1505): 1.4e-19: 98.2: 14.33
+	Sc
		375591 RPC1_YEAST (11-1471): 0: 1356: 32.85		STH1_YEAST (1216-1505): 1.4e-19: 98.2: 14.33
+	Sc
		501341 RPA1_YEAST (11-1472): 0: 1134: 22.98		STH1_YEAST (1216-1505): 1.4e-19: 98.2: 14.33
+	Dm
		375643 RPB1_DROME (1576-1967): 1.09e-22: 108: 46.33		BRM_DROME (21-1578): 0: 881: 50.85
+	Hs
		229264 RPA1_HUMAN (960-1473): 4.35e-38: 159: 16.12		SMCA5_HUMAN (610-1584): 0: 803: 27.43