Interactor 1: RPB1 (P24928)
DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)
Gene: POLR2A

Interactor 2: TF2B (Q00403)
Transcription initiation factor IIB (EC 2.3.1.48) (General transcription factor TFIIB) (S300-II)
Gene: GTF2B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.74 1.00 0.866

The method score is based on:

Property Details
Experiments 9159119, 35271311, 17643375
Identification Methods biochemical, pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type association, direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains RNA_pol_Rpb1_1~TF_Zn_Ribbon, RNA_pol_Rpb1_2~TF_Zn_Ribbon
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005694 - chromosome
GO:0006366 - transcription by RNA polymerase II
GO:0008270 - zinc ion binding
and 1 others

more...

Homologous interactions 5

Homologous interactions

Color coding for hit scores

1 1970
Hs

1 316
+ Hs
+ Sc
+ Sc
+ Sc
+ Sc

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Last updated: 15 Jul 2024