HitPredict

Interactor 1: RPB1 (P24928)
DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)
Gene: POLR2A

Interactor 2: KMT2A (Q03164)
Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
Gene: KMT2A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	34349018, 16199523
Identification Methods	cross-linking study, affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0008270 - zinc ion binding
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1970 Hs			1 3969
+	Hs
		624909 RPB1_HUMAN (1-1611): 0: 1858: 100.00		EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54
+	Hs
		625023 RPB1_HUMAN (1-1611): 0: 1858: 100.00		SETD2_HUMAN (3398-3968): 1.14e-75: 285: 16.61
+	Hs
		625100 RPB1_HUMAN (1-1611): 0: 1858: 100.00		SET1B_HUMAN (3529-3969): 1.64e-66: 254: 27.12
+	Hs
		165628 RPB1_HUMAN (1-1611): 0: 1858: 100.00		SET1A_HUMAN (3695-3969): 8.18e-56: 218: 34.58
+	Mm
		444974 RPB1_MOUSE (1-1611): 0: 1858: 100.00		NSD2_MOUSE (3752-3968): 6.91e-55: 215: 27.68
+	Hs
		152591 RPB1_HUMAN (1-1611): 0: 1858: 100.00		KMT2D_HUMAN (11-1393): 8.17e-09: 64.4: 10.47
+	Sp
		736917 RPB1_SCHPO (11-1576): 0: 1516: 53.18		SET1_SCHPO (3434-3969): 1.62e-77: 281: 22.46
+	Sp
		144173 RPB1_SCHPO (11-1576): 0: 1516: 53.18		SET2_SCHPO (3802-3968): 3.34e-56: 214: 32.57
+	Sc
		375383 RPB1_YEAST (11-1592): 0: 1458: 48.49		SET1_YEAST (3466-3969): 6.89e-73: 270: 21.67
+	Sc
		375432 RPB1_YEAST (11-1592): 0: 1458: 48.49		SET2_YEAST (3811-3968): 1.56e-56: 214: 29.56
+	Dm
		375641 RPB1_DROME (1576-1967): 1.09e-22: 108: 46.33		TRX_DROME (3633-3969): 3.49e-71: 270: 43.54