HitPredict

Interactor 1: RPB1 (P24928)
DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)
Gene: POLR2A

Interactor 2: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	16055720, 26508657
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1970 Hs			1 903
+	Hs
		625031 RPB1_HUMAN (1-1611): 0: 1858: 100.00		WWP1_HUMAN (1-903): 0: 832: 57.54
+	Mm
		444988 RPB1_MOUSE (1-1611): 0: 1858: 100.00		WWP2_MOUSE (1-903): 0: 820: 54.52
+	Hs
		125161 RPB1_HUMAN (1-1611): 0: 1858: 100.00		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		624804 RPB1_HUMAN (1-1611): 0: 1858: 100.00		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		625052 RPB1_HUMAN (1-1611): 0: 1858: 100.00		SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71
+	Hs
		156002 RPC1_HUMAN (16-1484): 0: 1349: 33.36		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Sc
		375492 RPB1_YEAST (11-1592): 0: 1458: 48.49		TOM1_YEAST (487-902): 5.57e-156: 510: 39.10
+	Sc
		501407 RPA1_YEAST (11-1472): 0: 1134: 22.98		TOM1_YEAST (487-902): 5.57e-156: 510: 39.10
+	Sc
		375403 RPB1_YEAST (11-1592): 0: 1458: 48.49		RSP5_YEAST (16-440): 9.75e-40: 160: 19.07
+	Dm
		1374363 Q9VUH6_DROME (1418-1857): 4.26e-10: 67.6: 13.68		SUDX_DROME (19-903): 0: 788: 48.29