HitPredict

Interactor 1: RPB1 (P24928)
DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)
Gene: POLR2A

Interactor 2: RPR1A (Q96P16)
Regulation of nuclear pre-mRNA domain-containing protein 1A (Cyclin-dependent kinase inhibitor 2B-related protein) (p15INK4B-related protein)
Gene: RPRD1A

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	24981860, 24997600
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1970 Hs			1 312
+	Hs
		625059 RPB1_HUMAN (1-1611): 0: 1858: 100.00		RPR1B_HUMAN (1-312): 6.18e-86: 262: 65.34
+	Hs
		624925 RPB1_HUMAN (1-1611): 0: 1858: 100.00		RPRD2_HUMAN (9-308): 1.26e-69: 236: 26.84
+	Hs
		300401 RPB1_HUMAN (1-1611): 0: 1858: 100.00		PCF11_HUMAN (9-229): 1.37e-45: 167: 20.26
+	Hs
		304587 RPB1_HUMAN (1-1611): 0: 1858: 100.00		SCAF4_HUMAN (8-271): 4.99e-45: 165: 17.88
+	Hs
		156051 RPC1_HUMAN (16-1484): 0: 1349: 33.36		RPR1A_HUMAN (1-312): 1.38e-104: 309: 100.00
+	Sc
		375505 RPB1_YEAST (11-1592): 0: 1458: 48.49		RT103_YEAST (4-304): 1.57e-44: 158: 19.74
+	Sc
		375396 RPB1_YEAST (11-1592): 0: 1458: 48.49		PCF11_YEAST (9-240): 6.67e-43: 157: 14.16
+	Hs
		156070 RPC1_HUMAN (16-1484): 0: 1349: 33.36		RPR1B_HUMAN (1-312): 6.18e-86: 262: 65.34
+	Sp
		736915 RPB1_SCHPO (11-1576): 0: 1516: 53.18		SEB1_SCHPO (1-309): 3.96e-13: 71.5: 11.30
+	Hs
		156026 RPC1_HUMAN (16-1484): 0: 1349: 33.36		RPRD2_HUMAN (9-308): 1.26e-69: 236: 26.84
+	Hs
		317150 RPA1_HUMAN (960-1473): 4.35e-38: 159: 16.12		RPR1A_HUMAN (1-312): 1.38e-104: 309: 100.00
+	Hs
		317165 RPA1_HUMAN (960-1473): 4.35e-38: 159: 16.12		RPR1B_HUMAN (1-312): 6.18e-86: 262: 65.34
+	Hs
		317123 RPA1_HUMAN (960-1473): 4.35e-38: 159: 16.12		RPRD2_HUMAN (9-308): 1.26e-69: 236: 26.84
+	Dm
		90672 RPB1_DROME (1576-1967): 1.09e-22: 108: 46.33		E1JH68_DROME (7-216): 1.53e-38: 145: 17.83
+	Sp
		548211 RPA1_SCHPO (11-146): 2.86e-30: 133: 26.28		SEB1_SCHPO (1-309): 3.96e-13: 71.5: 11.30