HitPredict

Interactor 1: CDK2 (P24941)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
Gene: CDK2

Interactor 2: CDN1B (P46527)
Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1)
Gene: CDKN1B

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.997

The method score is based on:

Property Details
Experiments 26450989, 27175940, 21439954, 24632684, 12529437, 33854239, 25483085, 34591612, 12800980, 9724724, 8978686, 9311993, 15355997, 11940657, 18285702, 16782892, 17254967, 9660939, 15890360, 16326706 and 38 others

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Identification Methods affinity chromatography technology, pull down, enzymatic study, unspecified method, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, in-gel kinase assay, tandem affinity purification, surface plasmon resonance, footprinting
Interaction Type physical association, direct interaction, phosphorylation reaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains CDI~Pkinase
Common GO terms GO:0000082 - G1/S transition of mitotic cell cycle
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005768 - endosome
and 6 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 298
Hs

1 198
+ Rn
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+ Mm
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+ Xl
+ Xl
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+ Mm
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+ Xl
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+ Mm
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+ Hs
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+ Dm
+ Dm
+ Dm
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024