HitPredict

Interactor 1: CDK2 (P24941)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
Gene: CDK2

Interactor 2: CDN1C (P49918)
Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57Kip2)
Gene: CDKN1C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.968

Property	Details
Experiments	25852190, 26186194, 26496610, 28514442, 33961781, 23602568, 23455922
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CDI~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 298 Hs			1 316
+	Hs
		625186 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		CDN1A_HUMAN (17-148): 7.59e-31: 115: 29.20
+	Hs
		836898 CDK3_HUMAN (1-294): 1.8e-154: 435: 76.87		CDN1C_HUMAN (1-316): 3.21e-37: 137: 100.00
+	Rn
		139842 CDK2_RAT (1-298): 6.76e-167: 466: 98.66		O08769_RAT (9-201): 8.07e-25: 100: 24.35
+	Hs
		625207 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		CDN1B_HUMAN (9-201): 9.76e-25: 100: 21.76
+	Mm
		763415 CDK2_MOUSE (1-298): 1.06e-157: 445: 85.26		CDN1A_MOUSE (16-155): 5.85e-33: 121: 27.78
+	Mm
		803840 CDK2_MOUSE (1-298): 1.06e-157: 445: 85.26		CDN1B_MOUSE (9-201): 1.47e-28: 110: 23.83
+	Hs
		758188 CDK3_HUMAN (1-294): 1.8e-154: 435: 76.87		CDN1A_HUMAN (17-148): 7.59e-31: 115: 29.20
+	Hs
		414825 CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90		CDN1C_HUMAN (1-316): 3.21e-37: 137: 100.00
+	Xl
		1153623 Q6IRQ7_XENLA (1-296): 2.28e-162: 455: 90.20		Q91646_XENLA (26-155): 1.89e-17: 81.3: 28.46
+	Hs
		804104 CDK3_HUMAN (1-294): 1.8e-154: 435: 76.87		CDN1B_HUMAN (9-201): 9.76e-25: 100: 21.76
+	Xl
		616668 CDK2_XENLA (1-296): 8.04e-162: 453: 89.53		Q91646_XENLA (26-155): 1.89e-17: 81.3: 28.46
+	Hs
		625528 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		TITIN_HUMAN (92-310): 7.91e-10: 62.3: 9.77
+	Mm
		509470 CDK1_MOUSE (1-289): 8.74e-143: 405: 66.21		CDN1A_MOUSE (16-155): 5.85e-33: 121: 27.78
+	Hs
		414796 CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90		CDN1A_HUMAN (17-148): 7.59e-31: 115: 29.20
+	Hs
		758190 CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39		CDN1A_HUMAN (17-148): 7.59e-31: 115: 29.20
+	Hs
		414811 CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90		CDN1B_HUMAN (9-201): 9.76e-25: 100: 21.76
+	Rn
		974742 CDK5_RAT (1-292): 7.65e-138: 392: 59.39		SYNJ1_RAT (62-316): 8.86e-28: 115: 16.09
+	Hs
		804106 CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39		CDN1B_HUMAN (9-201): 9.76e-25: 100: 21.76
+	Xl
		724512 CDK1A_XENLA (1-291): 1.26e-143: 407: 67.12		Q91646_XENLA (26-155): 1.89e-17: 81.3: 28.46
+	Hs
		804108 CDK17_HUMAN (1-296): 1.29e-122: 362: 52.53		CDN1B_HUMAN (9-201): 9.76e-25: 100: 21.76