HitPredict

Interactor 1: CDK2 (P24941)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
Gene: CDK2

Interactor 2: SKP2 (Q13309)
S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/LRR-repeat protein 1) (p45skp2)
Gene: SKP2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	0.60	0.767

Property	Details
Experiments	10559858, 33422522, 19686743, 19270695, 20160477, 18604603, 22770219, 25852190, 26186194, 26496610, 28514442, 33961781, 9858587, 35271311, 36736316, 16979657, 9636170, 7553852, 23602568, 23455922 and 1 others more... 15355997
Identification Methods	pull down, affinity chromatography technology, x-ray crystallography, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000082 - G1/S transition of mitotic cell cycle GO:0000086 - G2/M transition of mitotic cell cycle GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 298 Hs			1 424
+	Hs
		960089 CDK3_HUMAN (1-294): 1.8e-154: 435: 76.87		SKP2_HUMAN (1-424): 3e-94: 291: 100.00
+	Hs
		414902 CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90		SKP2_HUMAN (1-424): 3e-94: 291: 100.00
+	Hs
		960280 CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39		SKP2_HUMAN (1-424): 3e-94: 291: 100.00
+	Dm
		618398 CDK1_DROME (1-289): 1.85e-139: 396: 63.45		Q7YZ95_DROME (75-405): 5.44e-45: 166: 32.54
+	Dm
		618452 CDK2_DROME (1-289): 6.59e-134: 383: 63.67		Q7YZ95_DROME (75-405): 5.44e-45: 166: 32.54