HitPredict

Interactor 1: CDK2 (P24941)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
Gene: CDK2

Interactor 2: EIF3A (Q14152)
Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185)
Gene: EIF3A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	21319273
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 298 Hs			1 1382
+	Sc
		339595 CDK1_YEAST (1-288): 3.57e-132: 378: 62.12		EIF3A_YEAST (7-893): 4.61e-76: 275: 23.40
+	Sc
		565560 PHO85_YEAST (3-290): 6.29e-131: 375: 54.88		EIF3A_YEAST (7-893): 4.61e-76: 275: 23.40
+	Hs
		625176 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		MYH9_HUMAN (55-1098): 6.44e-45: 180: 9.65
+	Hs
		625177 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		MYH10_HUMAN (46-929): 1.09e-34: 147: 10.53
+	Hs
		960130 CDK3_HUMAN (1-294): 1.8e-154: 435: 76.87		MYH15_HUMAN (61-1134): 5.92e-34: 145: 9.34
+	Hs
		528401 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		MYH8_HUMAN (849-1382): 9.44e-20: 98.5: 7.87
+	Hs
		960129 CDK3_HUMAN (1-294): 1.8e-154: 435: 76.87		MYH13_HUMAN (638-1382): 4.53e-29: 128: 8.77
+	Hs
		625446 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		PLEC_HUMAN (497-1343): 1.73e-18: 94.5: 13.97
+	Hs
		502908 CDK3_HUMAN (1-294): 1.8e-154: 435: 76.87		MYH3_HUMAN (355-1375): 4.75e-28: 125: 9.20
+	Hs
		960128 CDK3_HUMAN (1-294): 1.8e-154: 435: 76.87		MYH2_HUMAN (36-853): 1.99e-23: 110: 10.32
+	Hs
		724717 CDK7_HUMAN (2-298): 9.81e-124: 359: 44.00		MYH9_HUMAN (55-1098): 6.44e-45: 180: 9.65
+	Hs
		528368 CDK3_HUMAN (1-294): 1.8e-154: 435: 76.87		MYH6_HUMAN (366-1087): 4.95e-21: 102: 10.45
+	Hs
		551610 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		DESP_HUMAN (478-1060): 3.57e-11: 70.4: 13.18
+	Hs
		528405 CDK3_HUMAN (1-294): 1.8e-154: 435: 76.87		MYH8_HUMAN (849-1382): 9.44e-20: 98.5: 7.87
+	Hs
		625530 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		MY18A_HUMAN (532-955): 1.34e-09: 65.3: 16.18
+	Hs
		522542 CDK3_HUMAN (1-294): 1.8e-154: 435: 76.87		MYH1_HUMAN (83-1022): 3.5e-18: 93.2: 10.72
+	Hs
		522604 CDK3_HUMAN (1-294): 1.8e-154: 435: 76.87		MYH7_HUMAN (83-989): 5.61e-18: 92.8: 10.62
+	Hs
		725114 CDK7_HUMAN (2-298): 9.81e-124: 359: 44.00		MYH10_HUMAN (46-929): 1.09e-34: 147: 10.53
+	Hs
		414713 CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90		DESP_HUMAN (478-1060): 3.57e-11: 70.4: 13.18
+	Hs
		841244 CDK7_HUMAN (2-298): 9.81e-124: 359: 44.00		ANR11_HUMAN (540-1374): 7.75e-10: 66: 14.59