HitPredict

Interactor 1: CDK2 (P24941)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
Gene: CDK2

Interactor 2: CCNJ (Q5T5M9)
Cyclin-J
Gene: CCNJ

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	33961781, 23455922
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cyclin_C~Pkinase, Cyclin_N~Pkinase
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005813 - centrosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 298 Hs			1 372
+	Hs
		625350 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		CCNA1_HUMAN (9-273): 4.17e-87: 272: 22.59
+	Hs
		625508 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		CCNJL_HUMAN (3-372): 3.14e-87: 271: 36.55
+	Hs
		538471 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		CCNB1_HUMAN (2-273): 1.04e-83: 263: 18.35
+	Hs
		303829 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		CCNB2_HUMAN (2-269): 4.24e-81: 254: 20.07
+	Hs
		590125 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		CCNA2_HUMAN (9-270): 1.97e-79: 251: 22.85
+	Mm
		956329 CDK2_MOUSE (1-298): 1.06e-157: 445: 85.26		CCNA1_MOUSE (4-273): 3.52e-86: 268: 23.27
+	Hs
		538521 CDK3_HUMAN (1-294): 1.8e-154: 435: 76.87		CCNB1_HUMAN (2-273): 1.04e-83: 263: 18.35
+	Mm
		851183 CDK2_MOUSE (1-298): 1.06e-157: 445: 85.26		CCNA2_MOUSE (5-272): 2.34e-80: 253: 21.98
+	At
		621689 CDKA1_ARATH (1-289): 1.02e-144: 410: 68.62		CCA32_ARATH (3-280): 1.97e-92: 283: 22.57
+	Hs
		624539 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		CCNE1_HUMAN (6-318): 1.47e-69: 225: 15.48
+	Hs
		590162 CDK3_HUMAN (1-294): 1.8e-154: 435: 76.87		CCNA2_HUMAN (9-270): 1.97e-79: 251: 22.85
+	At
		48929 CDKA1_ARATH (1-289): 1.02e-144: 410: 68.62		CCA33_ARATH (3-277): 1.06e-87: 269: 24.21
+	At
		621662 CDKA1_ARATH (1-289): 1.02e-144: 410: 68.62		CCA21_ARATH (3-275): 2.38e-85: 267: 20.64
+	At
		621690 CDKA1_ARATH (1-289): 1.02e-144: 410: 68.62		CCA11_ARATH (4-274): 2.14e-84: 265: 20.43
+	At
		621664 CDKA1_ARATH (1-289): 1.02e-144: 410: 68.62		CCA34_ARATH (5-277): 1.19e-84: 263: 22.18
+	At
		621653 CDKA1_ARATH (1-289): 1.02e-144: 410: 68.62		CCA22_ARATH (3-275): 1.22e-83: 262: 21.71
+	At
		621660 CDKA1_ARATH (1-289): 1.02e-144: 410: 68.62		CCA23_ARATH (2-274): 2.34e-83: 262: 23.13
+	At
		621661 CDKA1_ARATH (1-289): 1.02e-144: 410: 68.62		CCB12_ARATH (2-272): 4.91e-82: 258: 19.64
+	At
		621643 CDKA1_ARATH (1-289): 1.02e-144: 410: 68.62		CCB11_ARATH (2-276): 8.4e-81: 255: 20.42
+	Hs
		624573 CDK3_HUMAN (1-294): 1.8e-154: 435: 76.87		CCNE1_HUMAN (6-318): 1.47e-69: 225: 15.48