HitPredict

Interactor 1: CDK2 (P24941)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
Gene: CDK2

Interactor 2: Q8WUE3 (Q8WUE3)
CCNE2 protein (Cyclin E2)
Gene: CCNE2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	26496610
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Cyclin_C~Pkinase, Cyclin_N~Pkinase
Common GO terms	GO:0000082 - G1/S transition of mitotic cell cycle GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0051301 - cell division GO:0097134 - cyclin E1-CDK2 complex and 1 others more... GO:0097135 - cyclin E2-CDK2 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 298 Hs			1 374
+	Hs
		331629 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		CCNE2_HUMAN (1-370): 8.1e-112: 334: 99.19
+	Hs
		624539 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		CCNE1_HUMAN (1-368): 7e-110: 329: 49.87
+	Rn
		70081 Q6P751_RAT (1-298): 2.28e-166: 465: 98.99		B1WC54_RAT (1-368): 6.19e-107: 321: 47.85
+	Hs
		538471 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		CCNB1_HUMAN (2-367): 1.56e-100: 306: 20.91
+	Hs
		303829 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		CCNB2_HUMAN (1-362): 1.06e-100: 305: 21.45
+	Xl
		193809 CDK2_XENLA (1-296): 8.04e-162: 453: 89.53		CCNE3_XENLA (1-367): 2.25e-105: 317: 45.68
+	Hs
		331637 CDK3_HUMAN (1-294): 1.8e-154: 435: 76.87		CCNE2_HUMAN (1-370): 8.1e-112: 334: 99.19
+	Mm
		956330 CDK2_MOUSE (1-298): 1.06e-157: 445: 85.26		CCNE1_MOUSE (1-368): 4.11e-107: 322: 48.24
+	Hs
		624573 CDK3_HUMAN (1-294): 1.8e-154: 435: 76.87		CCNE1_HUMAN (1-368): 7e-110: 329: 49.87
+	Hs
		625350 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		CCNA1_HUMAN (106-367): 3.43e-91: 283: 25.56
+	Hs
		538521 CDK3_HUMAN (1-294): 1.8e-154: 435: 76.87		CCNB1_HUMAN (2-367): 1.56e-100: 306: 20.91
+	Hs
		590125 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		CCNA2_HUMAN (2-366): 2.38e-87: 272: 18.73
+	Mm
		956329 CDK2_MOUSE (1-298): 1.06e-157: 445: 85.26		CCNA1_MOUSE (106-366): 5.33e-88: 273: 25.65
+	Hs
		610197 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		CCNO_HUMAN (14-301): 5.05e-79: 248: 22.22
+	Mm
		851183 CDK2_MOUSE (1-298): 1.06e-157: 445: 85.26		CCNA2_MOUSE (3-366): 2.22e-86: 269: 20.79
+	Hs
		590162 CDK3_HUMAN (1-294): 1.8e-154: 435: 76.87		CCNA2_HUMAN (2-366): 2.38e-87: 272: 18.73
+	Hs
		625156 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		CCND3_HUMAN (98-329): 2.5e-70: 223: 25.31
+	At
		48929 CDKA1_ARATH (1-289): 1.02e-144: 410: 68.62		CCA33_ARATH (51-366): 4.18e-90: 275: 21.95
+	Hs
		610205 CDK3_HUMAN (1-294): 1.8e-154: 435: 76.87		CCNO_HUMAN (14-301): 5.05e-79: 248: 22.22
+	Hs
		673140 CDK3_HUMAN (1-294): 1.8e-154: 435: 76.87		CCND3_HUMAN (98-329): 2.5e-70: 223: 25.31