HitPredict

Interactor 1: CCNC (P25008)
Cyclin-C
Gene: CycC

Interactor 2: CDK5 (P48609)
Cyclin-dependent kinase 5 homolog (EC 2.7.11.22) (Cell division protein kinase 5)
Gene: CDK5

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.785

Property	Details
Experiments	15575970, 16603075
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Cyclin_C_2~Pkinase, Cyclin_N~Pkinase
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 267 Dm			1 294
+	Hs
		625350 CCNA1_HUMAN (10-265): 6.46e-81: 252: 18.77		CDK2_HUMAN (1-294): 6.23e-145: 410: 56.76
+	Hs
		538471 CCNB1_HUMAN (1-266): 2.99e-79: 247: 15.19		CDK2_HUMAN (1-294): 6.23e-145: 410: 56.76
+	Hs
		538521 CCNB1_HUMAN (1-266): 2.99e-79: 247: 15.19		CDK3_HUMAN (1-293): 1.25e-142: 405: 56.80
+	Mm
		956329 CCNA1_MOUSE (10-265): 4.58e-80: 249: 18.39		CDK2_MOUSE (1-294): 8.89e-137: 392: 48.98
+	Hs
		414855 CCNA1_HUMAN (10-265): 6.46e-81: 252: 18.77		CDK1_HUMAN (1-291): 1.77e-135: 386: 53.24
+	Hs
		538522 CCNB1_HUMAN (1-266): 2.99e-79: 247: 15.19		CDK5_HUMAN (1-292): 2.59e-137: 391: 78.08
+	Hs
		414711 CCNB1_HUMAN (1-266): 2.99e-79: 247: 15.19		CDK1_HUMAN (1-291): 1.77e-135: 386: 53.24
+	Mm
		851183 CCNA2_MOUSE (7-266): 3.28e-77: 241: 15.79		CDK2_MOUSE (1-294): 8.89e-137: 392: 48.98
+	At
		621662 CCA21_ARATH (2-267): 1.87e-76: 240: 15.52		CDKA1_ARATH (1-290): 1.64e-135: 386: 54.80
+	At
		621689 CCA32_ARATH (1-263): 3.13e-77: 240: 13.14		CDKA1_ARATH (1-290): 1.64e-135: 386: 54.80
+	Mm
		509476 CCNA2_MOUSE (7-266): 3.28e-77: 241: 15.79		CDK1_MOUSE (1-291): 2.94e-134: 383: 53.58
+	At
		1319943 CCA32_ARATH (1-263): 3.13e-77: 240: 13.14		CDKD1_ARATH (2-292): 8.65e-130: 376: 45.70
+	Hs
		841297 CCNL2_HUMAN (16-257): 9.15e-79: 248: 26.40		CDK7_HUMAN (2-292): 1.56e-127: 368: 42.18
+	At
		1323943 CCT15_ARATH (2-248): 8e-76: 242: 24.14		CDKC1_ARATH (1-292): 4.54e-127: 373: 39.68
+	Hs
		538497 CCNB1_HUMAN (1-266): 2.99e-79: 247: 15.19		CDK7_HUMAN (2-292): 1.56e-127: 368: 42.18
+	At
		1210031 CCT14_ARATH (2-249): 9.16e-76: 241: 23.66		CDKC1_ARATH (1-292): 4.54e-127: 373: 39.68
+	At
		1103352 CCA21_ARATH (2-267): 1.87e-76: 240: 15.52		CKB12_ARATH (1-292): 4.98e-130: 373: 47.91
+	At
		1106945 CCA21_ARATH (2-267): 1.87e-76: 240: 15.52		CKB21_ARATH (1-291): 7.16e-128: 368: 48.84
+	At
		1319944 CCA32_ARATH (1-263): 3.13e-77: 240: 13.14		CDKD3_ARATH (2-292): 2.09e-126: 367: 45.02
+	At
		639343 CCA21_ARATH (2-267): 1.87e-76: 240: 15.52		CKB11_ARATH (1-292): 1.23e-120: 349: 48.22