HitPredict

Interactor 1: CXCR1 (P25024)
C-X-C chemokine receptor type 1 (CXC-R1) (CXCR-1) (CDw128a) (High affinity interleukin-8 receptor A) (IL-8R A) (IL-8 receptor type 1) (CD antigen CD181)
Gene: CXCR1

Interactor 2: CXCL5 (P42830)
C-X-C motif chemokine 5 (ENA-78(1-78)) (Epithelial-derived neutrophil-activating protein 78) (Neutrophil-activating peptide ENA-78) (Small-inducible cytokine B5) [Cleaved into: ENA-78(8-78); ENA-78(9-78)]
Gene: CXCL5

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	8702798, 9485196
Identification Methods	biochemical, competition binding
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0030593 - neutrophil chemotaxis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 350 Hs			1 114
+	Hs
		625737 CXCR1_HUMAN (1-340): 2.74e-73: 232: 100.00		CXCL6_HUMAN (1-114): 2.69e-34: 116: 79.83
+	Hs
		364080 CXCR3_HUMAN (1-349): 6.16e-77: 242: 37.61		PLF4_HUMAN (34-109): 4.27e-26: 95.1: 42.11
+	Mm
		500672 CXCR2_MOUSE (3-339): 5.77e-73: 232: 69.23		CXCL2_MOUSE (38-112): 1.1e-28: 101: 49.33
+	Mm
		522397 CXCR2_MOUSE (3-339): 5.77e-73: 232: 69.23		GROA_MOUSE (39-109): 6.8e-28: 99.4: 53.52
+	Hs
		364041 CXCR1_HUMAN (1-340): 2.74e-73: 232: 100.00		CXCL7_HUMAN (43-114): 4.05e-27: 98.6: 50.00
+	Hs
		849615 CCR3_HUMAN (33-346): 2.05e-79: 248: 31.56		CXCL9_HUMAN (39-105): 1.52e-20: 81.6: 39.71
+	Mm
		291525 CXCR3_MOUSE (1-335): 2.34e-77: 243: 37.39		CXCL9_MOUSE (37-105): 2.18e-22: 86.3: 38.57
+	Hs
		150319 CCR3_HUMAN (33-346): 2.05e-79: 248: 31.56		CXL11_HUMAN (35-109): 1.33e-20: 80.9: 23.38
+	Hs
		364107 CCR3_HUMAN (33-346): 2.05e-79: 248: 31.56		CXL10_HUMAN (36-114): 3.23e-20: 80.1: 25.93
+	Hs
		448987 CXCR1_HUMAN (1-340): 2.74e-73: 232: 100.00		GROA_HUMAN (43-112): 2.33e-26: 95.9: 50.00
+	Mm
		291524 CXCR3_MOUSE (1-335): 2.34e-77: 243: 37.39		CXL10_MOUSE (36-113): 8.31e-22: 84: 26.25
+	Hs
		217751 CXCR3_HUMAN (1-349): 6.16e-77: 242: 37.61		CXL13_HUMAN (45-112): 4.22e-21: 82.4: 24.64
+	Hs
		830623 CXCR3_HUMAN (1-349): 6.16e-77: 242: 37.61		CXCL9_HUMAN (39-105): 1.52e-20: 81.6: 39.71
+	Hs
		150317 CXCR3_HUMAN (1-349): 6.16e-77: 242: 37.61		CXL11_HUMAN (35-109): 1.33e-20: 80.9: 23.38
+	Hs
		364105 CXCR3_HUMAN (1-349): 6.16e-77: 242: 37.61		CXL10_HUMAN (36-114): 3.23e-20: 80.1: 25.93
+	Hs
		486184 CXCR1_HUMAN (1-340): 2.74e-73: 232: 100.00		IL8_HUMAN (44-113): 8.67e-24: 89: 36.62
+	Hs
		364042 CXCR2_HUMAN (1-349): 3.91e-65: 212: 75.07		CXCL7_HUMAN (43-114): 4.05e-27: 98.6: 50.00
+	Hs
		448988 CXCR2_HUMAN (1-349): 3.91e-65: 212: 75.07		GROA_HUMAN (43-112): 2.33e-26: 95.9: 50.00
+	Hs
		217747 CXCR5_HUMAN (12-349): 1.84e-67: 218: 33.24		CXL13_HUMAN (45-112): 4.22e-21: 82.4: 24.64
+	Hs
		217753 ACKR4_HUMAN (3-349): 7.98e-66: 213: 28.82		CXL13_HUMAN (45-112): 4.22e-21: 82.4: 24.64