HitPredict

Interactor 1: PSB2 (P25043)
Proteasome subunit beta type-2 (EC 3.4.25.1) (Macropain subunit PUP1) (Multicatalytic endopeptidase complex subunit PUP1) (Proteasome component PUP1) (Proteinase YSCE subunit PUP1)
Gene: PUP1

Interactor 2: PSA6 (P40302)
Proteasome subunit alpha type-6 (Macropain subunit PRE5) (Multicatalytic endopeptidase complex subunit PRE5) (Proteasome component PRE5) (Proteinase YSCE subunit PRE5)
Gene: PRE5

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	16554755, 37968396
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pr_beta_C~Proteasome, Proteasome~Proteasome, Proteasome~Proteasome_A_N
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0010499 - proteasomal ubiquitin-independent protein catabolic process GO:0034515 - proteasome storage granule GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 261 Sc			1 234
+	Hs
		637732 PSB7_HUMAN (1-258): 5.68e-84: 253: 54.75		PSA2_HUMAN (1-234): 6.67e-103: 299: 28.81
+	Hs
		637640 PSB10_HUMAN (2-258): 8.39e-83: 250: 46.15		PSA2_HUMAN (1-234): 6.67e-103: 299: 28.81
+	Dm
		522528 Q9W470_DROME (2-257): 1.08e-83: 254: 44.92		PSA1_DROME (1-234): 5.39e-94: 278: 46.64
+	Hs
		637527 PSB7_HUMAN (1-258): 5.68e-84: 253: 54.75		PSA1_HUMAN (1-234): 2.47e-94: 278: 52.77
+	Hs
		637346 PSB10_HUMAN (2-258): 8.39e-83: 250: 46.15		PSA1_HUMAN (1-234): 2.47e-94: 278: 52.77
+	Dm
		1369058 Q9VUJ1_DROME (2-258): 8.36e-82: 248: 54.09		Q9VK14_DROME (1-234): 2.57e-94: 279: 46.58
+	Sp
		145200 PSA5_SCHPO (3-231): 1.73e-82: 248: 21.25		PSA6_SCHPO (1-226): 1.45e-94: 279: 61.67
+	Dm
		522522 Q9VUJ1_DROME (2-258): 8.36e-82: 248: 54.09		PSA1_DROME (1-234): 5.39e-94: 278: 46.64
+	Hs
		156341 PSB7_HUMAN (1-258): 5.68e-84: 253: 54.75		PSA7_HUMAN (6-234): 5.17e-92: 272: 31.47
+	Hs
		656296 PSB7_HUMAN (1-258): 5.68e-84: 253: 54.75		PSA5_HUMAN (1-234): 3.29e-92: 272: 30.71
+	Hs
		638179 PSB7_HUMAN (1-258): 5.68e-84: 253: 54.75		PSA4_HUMAN (1-234): 1.89e-91: 271: 31.95
+	Dm
		1278650 Q9VUJ1_DROME (2-258): 8.36e-82: 248: 54.09		PSA5_DROME (1-234): 5.2e-93: 274: 31.28
+	Hs
		656164 PSB10_HUMAN (2-258): 8.39e-83: 250: 46.15		PSA5_HUMAN (1-234): 3.29e-92: 272: 30.71
+	Dm
		574054 Q9W470_DROME (2-257): 1.08e-83: 254: 44.92		PSA4_DROME (1-234): 3.49e-89: 265: 30.71
+	Hs
		1250771 PSB7_HUMAN (1-258): 5.68e-84: 253: 54.75		PSMA8_HUMAN (4-234): 3.16e-89: 265: 31.25
+	Hs
		893733 PSB7_HUMAN (1-258): 5.68e-84: 253: 54.75		PSA6_HUMAN (1-234): 2.43e-89: 265: 24.79
+	Dm
		574048 Q9VUJ1_DROME (2-258): 8.36e-82: 248: 54.09		PSA4_DROME (1-234): 3.49e-89: 265: 30.71
+	Sc
		675421 PSB5_YEAST (29-221): 2.42e-81: 247: 28.21		PSA6_YEAST (1-234): 1.96e-89: 265: 100.00
+	Sc
		625917 PSB2_YEAST (1-261): 6.21e-92: 273: 100.00		PSA5_YEAST (3-234): 1.78e-32: 120: 34.44
+	Sc
		675397 PSB5_YEAST (29-221): 2.42e-81: 247: 28.21		PSA5_YEAST (3-234): 1.78e-32: 120: 34.44