HitPredict

Interactor 1: ARBK1 (P25098)
Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (EC 2.7.11.15) (G-protein coupled receptor kinase 2)
Gene: GRK2

Interactor 2: ARBK1 (P25098)
Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (EC 2.7.11.15) (G-protein coupled receptor kinase 2)
Gene: GRK2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.38 1.00 0.618

The method score is based on:

Property Details
Experiments 35271311
Identification Methods affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains PH~PH, PH~Pkinase, Pkinase~Pkinase, Pkinase~RGS, RGS~RGS
Common GO terms GO:0001664 - G protein-coupled receptor binding
GO:0002026 - regulation of the force of heart contraction
GO:0002029 - desensitization of G protein-coupled receptor signaling pathway
GO:0003108 - negative regulation of the force of heart contraction by chemical signal
GO:0004672 - protein kinase activity
and 24 others

more...
Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 689
Hs

1 689
+ Hs
+ Rn
+ At
+ Ps
+ At
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024