HitPredict

Interactor 1: ARBK1 (P25098)
Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (EC 2.7.11.15) (G-protein coupled receptor kinase 2)
Gene: GRK2

Interactor 2: GBB1 (P62873)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1)
Gene: GNB1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.834

Property	Details
Experiments	15102938, 17548351, 10744734
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PH~WD40, RGS~WD40
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007186 - G protein-coupled receptor signaling pathway GO:0007213 - G protein-coupled acetylcholine receptor signaling pathway and 1 others more... GO:0016020 - membrane
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 689 Hs			1 340
+	Hs
		626637 ARBK1_HUMAN (1-689): 0: 654: 100.00		GBB2_HUMAN (1-340): 1e-105: 314: 90.29
+	Hs
		560859 ARBK1_HUMAN (1-689): 0: 654: 100.00		GBB3_HUMAN (1-340): 1.83e-104: 311: 83.24
+	Mm
		921105 ARBK1_MOUSE (1-689): 0: 653: 98.84		GBB1_MOUSE (1-340): 7.02e-105: 312: 100.00
+	Hs
		682161 AKT2_HUMAN (68-517): 4.7e-142: 425: 27.96		GBB1_HUMAN (1-340): 7.02e-105: 312: 100.00
+	Hs
		681771 AKT1_HUMAN (68-515): 3.49e-140: 420: 26.41		GBB1_HUMAN (1-340): 7.02e-105: 312: 100.00
+	Hs
		196956 ARBK1_HUMAN (1-689): 0: 654: 100.00		PRP4_HUMAN (51-253): 1.06e-12: 70.5: 25.85
+	Dm
		1213409 AKT1_DROME (140-511): 3.33e-137: 417: 28.95		NLE_DROME (131-339): 1.57e-47: 168: 22.57
+	Dm
		640819 GPRK2_DROME (144-524): 5.69e-79: 268: 41.43		GBB1_DROME (1-340): 1.54e-103: 309: 83.53
+	Dm
		669785 GPRK2_DROME (144-524): 5.69e-79: 268: 41.43		GBB2_DROME (137-340): 2.67e-41: 149: 21.80