HitPredict

Interactor 1: NK1R (P25103)
Substance-P receptor (SPR) (NK-1 receptor) (NK-1R) (Tachykinin receptor 1)
Gene: TACR1

Interactor 2: CAV1 (Q03135)
Caveolin-1
Gene: CAV1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0032570 - response to progesterone GO:0045907 - positive regulation of vasoconstriction
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 407 Hs			1 178
+	Hs
		674844 AGTR1_HUMAN (7-355): 1.01e-67: 220: 20.45		CAV1_HUMAN (1-178): 2.82e-109: 310: 100.00
+	Mm
		578599 ADRB2_MOUSE (11-393): 4.14e-78: 249: 22.11		CAV3_MOUSE (35-177): 1.81e-76: 227: 65.73
+	Hs
		626734 NK1R_HUMAN (1-407): 5.52e-95: 292: 100.00		CAV2_HUMAN (53-177): 5.1e-59: 183: 40.80
+	Hs
		428989 ADRB2_HUMAN (11-391): 1e-75: 243: 20.99		CAV3_HUMAN (32-178): 1.22e-75: 224: 64.00