HitPredict

Interactor 1: PTAFR (P25105)
Platelet-activating factor receptor (PAF-R) (PAFr)
Gene: PTAFR

Interactor 2: TYK2 (P29597)
Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)
Gene: TYK2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	14500680, 11309383
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0006955 - immune response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 342 Hs			1 1187
+	Hs
		669140 LPAR6_HUMAN (5-314): 4.01e-82: 254: 28.80		TYK2_HUMAN (1-1187): 0: 997: 100.00
+	Hs
		669153 CXCR4_HUMAN (10-308): 1.05e-67: 217: 22.92		TYK2_HUMAN (1-1187): 0: 997: 100.00
+	Hs
		238386 CCR5_HUMAN (12-321): 1.93e-82: 255: 24.76		JAK2_HUMAN (28-1175): 0: 781: 36.09
+	Rn
		626617 AGTRA_RAT (11-341): 3.46e-67: 216: 24.32		JAK2_RAT (11-1175): 0: 783: 35.91
+	Hs
		238391 CXCR4_HUMAN (10-308): 1.05e-67: 217: 22.92		JAK2_HUMAN (28-1175): 0: 781: 36.09
+	Hs
		238359 PTAFR_HUMAN (1-342): 1.46e-66: 214: 100.00		JAK2_HUMAN (28-1175): 0: 781: 36.09
+	Hs
		238366 AGTR1_HUMAN (11-341): 2.5e-66: 214: 23.42		JAK2_HUMAN (28-1175): 0: 781: 36.09
+	Hs
		854164 CXCR4_HUMAN (10-308): 1.05e-67: 217: 22.92		JAK3_HUMAN (26-1185): 0: 727: 36.23
+	Hs
		522832 P2RY2_HUMAN (7-299): 1.72e-84: 261: 26.53		SRC_HUMAN (843-1182): 2.67e-99: 328: 28.57
+	Hs
		428898 ADRB2_HUMAN (7-317): 1.94e-70: 227: 15.34		SRC_HUMAN (843-1182): 2.67e-99: 328: 28.57
+	Rn
		706745 OPRM_RAT (4-341): 5.26e-68: 220: 21.18		SRC_RAT (843-1182): 3.89e-98: 324: 28.28
+	Hs
		433268 CCR1_HUMAN (13-339): 8.4e-66: 213: 22.26		YES_HUMAN (842-1182): 3.68e-98: 325: 27.91
+	Hs
		616762 LPAR6_HUMAN (5-314): 4.01e-82: 254: 28.80		JAK1_HUMAN (852-1178): 1.14e-34: 146: 19.54
+	Hs
		616748 APJ_HUMAN (5-337): 9.85e-73: 231: 23.44		JAK1_HUMAN (852-1178): 1.14e-34: 146: 19.54
+	Hs
		616777 CXCR4_HUMAN (10-308): 1.05e-67: 217: 22.92		JAK1_HUMAN (852-1178): 1.14e-34: 146: 19.54
+	Hs
		616743 AGTR1_HUMAN (11-341): 2.5e-66: 214: 23.42		JAK1_HUMAN (852-1178): 1.14e-34: 146: 19.54
+	Hs
		849649 CCR5_HUMAN (12-321): 1.93e-82: 255: 24.76		FAK1_HUMAN (600-869): 2.31e-16: 86.7: 28.01
+	Hs
		895612 CXCR4_HUMAN (10-308): 1.05e-67: 217: 22.92		FAK1_HUMAN (600-869): 2.31e-16: 86.7: 28.01
+	Hs
		626778 PTAFR_HUMAN (1-342): 1.46e-66: 214: 100.00		FAK1_HUMAN (600-869): 2.31e-16: 86.7: 28.01
+	Hs
		895632 CXCR4_HUMAN (10-308): 1.05e-67: 217: 22.92		NTRK3_HUMAN (627-869): 5.07e-13: 75.9: 25.00