HitPredict

Interactor 1: TNR1A (P25118)
Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a)
Gene: Tnfrsf1a

Interactor 2: TRADD (Q3U0V2)
Tumor necrosis factor receptor type 1-associated DEATH domain protein (TNFR1-associated DEATH domain protein) (TNFRSF1A-associated via death domain)
Gene: TRADD

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.69 1.00 0.834

The method score is based on:

Property Details
Experiments 19641494, 19150425, 10795740
Identification Methods anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Death~Death
Common GO terms GO:0005886 - plasma membrane
GO:0008625 - extrinsic apoptotic signaling pathway via death domain receptors
GO:0032991 - protein-containing complex
GO:0033209 - tumor necrosis factor-mediated signaling pathway
GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
and 3 others

more...
Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 454
Mm

1 310
+ Rn
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024