HitPredict

Interactor 1: TNR1A (P25118)
Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a)
Gene: Tnfrsf1a

Interactor 2: RIPK1 (Q60855)
Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1)
Gene: RIPK1

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.977

The method score is based on:

Property Details
Experiments 29891719, 29203883, 30209212, 36640323, 16547522, 23602765, 18719121, 15175328, 10795740, 17702576, 19150425, 18022363, 26649818, 16680093
Identification Methods affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Death~Death
Common GO terms GO:0006954 - inflammatory response
GO:0008625 - extrinsic apoptotic signaling pathway via death domain receptors
GO:0032760 - positive regulation of tumor necrosis factor production
GO:0032991 - protein-containing complex
GO:0033209 - tumor necrosis factor-mediated signaling pathway
and 8 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 454
Mm

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024