Interactor 1: CAN8 (A6NHC0)
Calpain-8 (EC 3.4.22.53) (New calpain 2) (nCL-2) (Stomach-specific M-type calpain)
Gene: CAPN8

Interactor 2: CAN1 (P07384)
Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP)
Gene: CAPN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.65 1.00 0.811

The method score is based on:

Property Details
Experiments 28514442, 33961781
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Calpain_III~EF-hand_8, Calpain_III~Peptidase_C2, Peptidase_C2~Peptidase_C2
Common GO terms GO:0004198 - calcium-dependent cysteine-type endopeptidase activity
GO:0005509 - calcium ion binding
GO:0005737 - cytoplasm
GO:0006508 - proteolysis
Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 703
Hs

1 714
+ Hs
+ Hs
+ Hs
+ Dm
+ Dm
+ Dm
+ Dm
+ Dm
+ Hs
+ Hs
+ Hs
+ Rn
+ Zm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024