HitPredict

Interactor 1: MCM3 (P25205)
DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102)
Gene: MCM3

Interactor 2: IKBA (P25963)
NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3)
Gene: NFKBIA

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	32912968, 14743216
Identification Methods	affinity chromatography technology, proximity labelling technology, tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 808 Hs			1 317
+	Hs
		627219 MCM3_HUMAN (1-808): 0: 944: 100.00		DAPK1_HUMAN (27-317): 1.12e-62: 216: 17.11
+	Hs
		627296 MCM3_HUMAN (1-808): 0: 944: 100.00		MIB1_HUMAN (187-313): 7.22e-23: 101: 18.11
+	Hs
		639680 MCM5_HUMAN (9-713): 0: 685: 28.92		IKBA_HUMAN (1-317): 2.59e-84: 258: 100.00
+	Hs
		639681 MCM7_HUMAN (10-669): 0: 650: 31.62		IKBA_HUMAN (1-317): 2.59e-84: 258: 100.00
+	Hs
		832413 MCM2_HUMAN (10-721): 0: 707: 30.62		ANK3_HUMAN (1-130): 1.86e-30: 123: 10.77
+	Hs
		1021402 MCM6_HUMAN (2-800): 0: 688: 26.50		ANK3_HUMAN (1-130): 1.86e-30: 123: 10.77
+	Hs
		708430 MCM4_HUMAN (9-739): 0: 661: 28.03		ANK3_HUMAN (1-130): 1.86e-30: 123: 10.77
+	Hs
		708966 MCM7_HUMAN (10-669): 0: 650: 31.62		MIB1_HUMAN (187-313): 7.22e-23: 101: 18.11
+	Hs
		587443 MCM7_HUMAN (10-669): 0: 650: 31.62		NFKB1_HUMAN (31-196): 3.47e-20: 93.1: 23.35