HitPredict

Interactor 1: MCM3 (P25205)
DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102)
Gene: MCM3

Interactor 2: H4 (P62805)
Histone H4
Gene: H4C1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.51	0.60	0.554

Property	Details
Experiments	19862764
Identification Methods	affinity chromatography technology, tandem affinity purification, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016020 - membrane
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 808 Hs			1 103
+	Hs
		832321 MCM2_HUMAN (10-721): 0: 707: 30.62		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		917263 MCM6_HUMAN (2-800): 0: 688: 26.50		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		708595 MCM5_HUMAN (9-713): 0: 685: 28.92		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		708413 MCM4_HUMAN (9-739): 0: 661: 28.03		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		708859 MCM7_HUMAN (10-669): 0: 650: 31.62		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Sc
		356302 MCM2_YEAST (6-668): 0: 664: 32.15		H4_YEAST (18-103): 6.13e-41: 132: 90.70
+	Sc
		356267 MCM3_YEAST (45-782): 0: 655: 44.49		H4_YEAST (18-103): 6.13e-41: 132: 90.70
+	Sc
		356306 MCM4_YEAST (9-804): 0: 654: 27.82		H4_YEAST (18-103): 6.13e-41: 132: 90.70
+	Sc
		356303 MCM5_YEAST (8-650): 1.72e-86: 292: 31.51		H4_YEAST (18-103): 6.13e-41: 132: 90.70