HitPredict

Interactor 1: MCM3 (P25205)
DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102)
Gene: MCM3

Interactor 2: TIM (Q9UNS1)
Protein timeless homolog (hTIM)
Gene: TIMELESS

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	28514442, 33961781, 21573113
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 808 Hs			1 1208
+	Hs
		832779 MCM2_HUMAN (10-721): 0: 707: 30.62		TIM_HUMAN (1-1208): 0: 1614: 100.00
+	Hs
		708801 MCM5_HUMAN (9-713): 0: 685: 28.92		TIM_HUMAN (1-1208): 0: 1614: 100.00
+	Hs
		709112 MCM7_HUMAN (10-669): 0: 650: 31.62		TIM_HUMAN (1-1208): 0: 1614: 100.00
+	Mm
		956199 MCM2_MOUSE (10-721): 0: 706: 30.07		TIM_MOUSE (1-1207): 0: 1520: 82.98
+	Sc
		667609 MCM2_YEAST (6-668): 0: 664: 32.15		TOF1_YEAST (25-559): 4.17e-112: 381: 21.50
+	Sc
		622180 MCM3_YEAST (45-782): 0: 655: 44.49		TOF1_YEAST (25-559): 4.17e-112: 381: 21.50
+	Sc
		675541 MCM4_YEAST (9-804): 0: 654: 27.82		TOF1_YEAST (25-559): 4.17e-112: 381: 21.50
+	Sp
		772838 MCM2_SCHPO (1-668): 0: 674: 32.31		SWI1_SCHPO (602-822): 5.03e-12: 72.6: 22.69
+	Sc
		744784 MCM7_YEAST (20-674): 8.95e-91: 305: 34.27		TOF1_YEAST (25-559): 4.17e-112: 381: 21.50
+	Sc
		667876 MCM5_YEAST (8-650): 1.72e-86: 292: 31.51		TOF1_YEAST (25-559): 4.17e-112: 381: 21.50