Interactor 1: NFS1 (P25374)
Cysteine desulfurase, mitochondrial (EC 2.8.1.7) (tRNA-splicing protein SPL1)
Gene: NFS1

Interactor 2: FRDA (Q07540)
Frataxin homolog, mitochondrial (EC 1.16.3.1) [Cleaved into: Frataxin homolog intermediate form]
Gene: YFH1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.87 1.00 0.933

The method score is based on:

Property Details
Experiments 28941588, 25228696, 29386296, 18319250, 35026224, 12947415
Identification Methods affinity chromatography technology, pull down
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Aminotran_5~Frataxin_Cyay
Common GO terms GO:0005739 - mitochondrion
GO:0006879 - intracellular iron ion homeostasis
GO:0016226 - iron-sulfur cluster assembly
GO:1990229 - iron-sulfur cluster assembly complex
Homologous interactions 4

Homologous interactions

Color coding for hit scores

1 497
Sc

1 174
+ Hs
+ At
+ Ec
+ Ec

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024