HitPredict

Interactor 1: FRMA (P25437)
S-(hydroxymethyl)glutathione dehydrogenase (EC 1.1.1.284) (Alcohol dehydrogenase class-3) (EC 1.1.1.1) (Alcohol dehydrogenase class-III) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH) (FDH) (GSH-FDH) (EC 1.1.1.-)
Gene: FRMA

Interactor 2: FRMA (P25437)
S-(hydroxymethyl)glutathione dehydrogenase (EC 1.1.1.284) (Alcohol dehydrogenase class-3) (EC 1.1.1.1) (Alcohol dehydrogenase class-III) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH) (FDH) (GSH-FDH) (EC 1.1.1.-)
Gene: FRMA

Species: Escherichia coli K-12

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.62 1.00 0.793

The method score is based on:

Property Details
Experiments 24561554, 16858726
Identification Methods two hybrid, blue native page, two hybrid array
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains ADH_N~ADH_N, ADH_N~ADH_zinc_N, ADH_zinc_N~ADH_zinc_N
Common GO terms GO:0004024 - alcohol dehydrogenase (NAD+) activity, zinc-dependent
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0008270 - zinc ion binding
GO:0046294 - formaldehyde catabolic process
and 3 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 369
Ec

1 369
+ At
+ Hs
+ Hs
+ Hs
+ Hs
+ At
+ Sc
+ Ce
+ Sc
+ Sc
+ Ph
+ Ce
+ Hs
+ Hs
+ Sc
+ Sc

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024