HitPredict - High confidence protein-protein interactions

Interactor 1: TNR6 (P25445)
Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95)
Gene: FAS

Interactor 2: TNR6 (P25445)
Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95)
Gene: FAS

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.945

Property	Details
Experiments	18328427, 7538908, 34917906, 8940097, 21382479, 7536190
Identification Methods	affinity chromatography technology, two hybrid, protein complementation assay, proximity labelling technology, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Death~Death, TNFR_c6~TNFR_c6
Common GO terms	GO:0001934 - positive regulation of protein phosphorylation GO:0005031 - tumor necrosis factor receptor activity GO:0005516 - calmodulin binding GO:0005829 - cytosol GO:0005886 - plasma membrane and 28 others more... GO:0006915 - apoptotic process GO:0006924 - activation-induced cell death of T cells GO:0006955 - immune response GO:0007165 - signal transduction GO:0009897 - external side of plasma membrane GO:0009986 - cell surface GO:0016604 - nuclear body GO:0019900 - kinase binding GO:0031264 - death-inducing signaling complex GO:0031265 - CD95 death-inducing signaling complex GO:0032872 - regulation of stress-activated MAPK cascade GO:0034198 - cellular response to amino acid starvation GO:0036337 - Fas signaling pathway GO:0038023 - signaling receptor activity GO:0042981 - regulation of apoptotic process GO:0043065 - positive regulation of apoptotic process GO:0043066 - negative regulation of apoptotic process GO:0045121 - membrane raft GO:0065003 - protein-containing complex assembly GO:0070062 - extracellular exosome GO:0071260 - cellular response to mechanical stimulus GO:0071455 - cellular response to hyperoxia GO:0097049 - motor neuron apoptotic process GO:0097191 - extrinsic apoptotic signaling pathway GO:0097192 - extrinsic apoptotic signaling pathway in absence of ligand GO:0097527 - necroptotic signaling pathway GO:2001235 - positive regulation of apoptotic signaling pathway GO:2001269 - positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1	335
Hs

1	335

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Last updated: 15 Jul 2024