HitPredict

Interactor 1: TNR6 (P25445)
Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95)
Gene: FAS

Interactor 2: TNFL6 (P48023)
Tumor necrosis factor ligand superfamily member 6 (Apoptosis antigen ligand) (APTL) (CD95 ligand) (CD95-L) (Fas antigen ligand) (Fas ligand) (FasL) (CD antigen CD178) [Cleaved into: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form (Receptor-binding FasL ectodomain) (Soluble Fas ligand) (sFasL); ADAM10-processed FasL form (APL); FasL intracellular domain (FasL ICD) (SPPL2A-processed FasL form) (SPA)]
Gene: FASLG

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 1.00 0.965

The method score is based on:

Property Details
Experiments 15659383, 9126929, 9228058, 12887920, 12753742, 21803845, 24025841
Identification Methods biochemical, pull down, affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type association, direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains TNF~TNFR_c6
Common GO terms GO:0005886 - plasma membrane
GO:0006915 - apoptotic process
GO:0007165 - signal transduction
GO:0009897 - external side of plasma membrane
GO:0043065 - positive regulation of apoptotic process
and 3 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 335
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024