HitPredict

Interactor 1: TNR6 (P25445)
Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95)
Gene: FAS

Interactor 2: FADD (Q13158)
FAS-associated death domain protein (FAS-associating death domain-containing protein) (Growth-inhibiting gene 3 protein) (Mediator of receptor induced toxicity)
Gene: FADD

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.994

The method score is based on:

Property Details
Experiments 10545115, 9990010, 9325248, 9082980, 8967952, 7538907, 12107169, 26186194, 27321185, 28514442, 18328427, 15659383, 29795330, 19483105, 20876301, 16554480, 33961781, 11035039, 22864571, 21382479 and 15 others

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Identification Methods affinity chromatography technology, pull down, x-ray crystallography, two hybrid, biochemical, 3D electron microscopy, transmission electron microscopy, molecular sieving, fluorescent resonance energy transfer, cosedimentation in solution and 5 others

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Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Death~Death
Common GO terms GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0006915 - apoptotic process
GO:0031264 - death-inducing signaling complex
GO:0031265 - CD95 death-inducing signaling complex
and 6 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024