HitPredict

Interactor 1: TNR6 (P25445)
Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95)
Gene: FAS

Interactor 2: CASP8 (Q14790)
Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]
Gene: CASP8

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 0.60 0.767

The method score is based on:

Property Details
Experiments 18328427, 11978827, 26186194, 27321185, 28514442, 15659383, 29795330, 18787411, 19483105, 9208847, 16554480, 9325248, 33961781, 34917906, 20956295, 26942442, 21713032, 15993755, 17047155, 17898872 and 6 others

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Identification Methods affinity chromatography technology, biochemical, proximity labelling technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005829 - cytosol
GO:0006915 - apoptotic process
GO:0031264 - death-inducing signaling complex
GO:0031265 - CD95 death-inducing signaling complex
GO:0043065 - positive regulation of apoptotic process
and 2 others

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Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 335
Hs

1 479
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024