HitPredict

Interactor 1: TNR6 (P25445)
Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95)
Gene: FAS

Interactor 2: FAF1 (Q9UNN5)
FAS-associated factor 1 (hFAF1) (UBX domain-containing protein 12) (UBX domain-containing protein 3A)
Gene: FAF1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.685

Property	Details
Experiments	10462485, 8524870, 12372427, 12702723
Identification Methods	pull down, affinity chromatography technology, two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0006915 - apoptotic process GO:0031265 - CD95 death-inducing signaling complex GO:0043065 - positive regulation of apoptotic process
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 335 Hs			1 650
+	Mm
		632461 TNR6_MOUSE (1-334): 6.92e-109: 322: 48.50		FAF1_MOUSE (1-650): 0: 844: 96.31
+	Hs
		639661 TNR5_HUMAN (43-229): 6.54e-36: 133: 19.58		FAF1_HUMAN (1-650): 0: 840: 100.00
+	Hs
		632349 TNR6_HUMAN (1-335): 2.61e-113: 333: 100.00		FAF2_HUMAN (320-649): 2.56e-68: 231: 22.29
+	Hs
		632393 TNR6_HUMAN (1-335): 2.61e-113: 333: 100.00		UBXN6_HUMAN (395-645): 7.43e-34: 136: 15.73
+	Hs
		116663 TNR6_HUMAN (1-335): 2.61e-113: 333: 100.00		UBXN8_HUMAN (434-650): 7.09e-34: 132: 22.58
+	Hs
		632251 TNR6_HUMAN (1-335): 2.61e-113: 333: 100.00		UBXN1_HUMAN (414-649): 9.29e-34: 132: 16.00
+	Hs
		591312 TNR1B_HUMAN (46-234): 8.6e-38: 141: 18.22		UBXN1_HUMAN (414-649): 9.29e-34: 132: 16.00