HitPredict

Interactor 1: TNR6 (P25446)
Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95)
Gene: Fas

Interactor 2: FADD (Q61160)
FAS-associated death domain protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity)
Gene: FADD

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.77 1.00 0.881

The method score is based on:

Property Details
Experiments 11978827, 21382479, 18455983, 17159908
Identification Methods affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Death~Death
Common GO terms GO:0002020 - protease binding
GO:0006915 - apoptotic process
GO:0008625 - extrinsic apoptotic signaling pathway via death domain receptors
GO:0031264 - death-inducing signaling complex
GO:0031265 - CD95 death-inducing signaling complex
and 7 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 327
Mm

1 205
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024