HitPredict

Interactor 1: PSB3 (P25451)
Proteasome subunit beta type-3 (Macropain subunit PUP3) (Multicatalytic endopeptidase complex subunit PUP3) (Proteasome component PUP3)
Gene: PUP3

Interactor 2: RPN10 (P38886)
26S proteasome regulatory subunit RPN10
Gene: RPN10

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.662

Property	Details
Experiments	11805826, 16429126, 37968396
Identification Methods	tandem affinity purification, affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 205 Sc			1 268
+	Hs
		656691 PSB5_HUMAN (8-205): 2.72e-67: 208: 21.11		PSMD4_HUMAN (1-236): 5.46e-119: 347: 49.15
+	Sc
		619972 PSB6_YEAST (3-205): 1.03e-73: 224: 22.52		RPN10_YEAST (1-268): 3.42e-114: 330: 100.00
+	Hs
		656185 PSA5_HUMAN (6-205): 1.89e-64: 200: 17.14		PSMD4_HUMAN (1-236): 5.46e-119: 347: 49.15
+	Hs
		656250 PSA5_HUMAN (6-205): 1.89e-64: 200: 17.14		Q5VWC4_HUMAN (1-236): 7.75e-119: 346: 49.15
+	Hs
		831965 PSB3_HUMAN (3-205): 5e-64: 198: 53.43		PSMD4_HUMAN (1-236): 5.46e-119: 347: 49.15
+	Hs
		594491 PSB1_HUMAN (3-205): 9.86e-63: 196: 23.47		PSMD4_HUMAN (1-236): 5.46e-119: 347: 49.15
+	Dm
		874030 Q7K148_DROME (4-205): 1.88e-67: 209: 23.65		PSMD4_DROME (1-256): 5.75e-113: 332: 41.80
+	Sc
		675417 PSB5_YEAST (4-195): 1.16e-64: 203: 22.80		RPN10_YEAST (1-268): 3.42e-114: 330: 100.00
+	Hs
		656101 PSB9_HUMAN (5-200): 6.23e-30: 111: 20.81		PSMD4_HUMAN (1-236): 5.46e-119: 347: 49.15
+	Hs
		656578 PSB6_HUMAN (5-200): 1.04e-28: 108: 18.78		PSMD4_HUMAN (1-236): 5.46e-119: 347: 49.15