HitPredict

Interactor 1: PWP2 (P25635)
Periodic tryptophan protein 2 (U three protein 1) (U3 small nucleolar RNA-associated protein 1) (U3 snoRNA-associated protein 1)
Gene: PWP2

Interactor 2: SPB4 (P25808)
ATP-dependent rRNA helicase SPB4 (EC 3.6.4.13) (Suppressor of PAB1 protein 4)
Gene: SPB4

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	21825077
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	ANAPC4_WD40~DEAD
Common GO terms	GO:0005654 - nucleoplasm GO:0005730 - nucleolus GO:0030686 - 90S preribosome
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 923 Sc			1 606
+	Sc
		635633 PWP2_YEAST (1-923): 0: 650: 100.00		HAS1_YEAST (6-467): 1.01e-156: 460: 30.98
+	Sc
		415901 PWP2_YEAST (1-923): 0: 650: 100.00		DED1_YEAST (3-402): 8.68e-139: 418: 25.55
+	Sc
		593593 PWP2_YEAST (1-923): 0: 650: 100.00		DBP4_YEAST (21-467): 7e-51: 189: 31.36
+	Hs
		1070052 PWP2_HUMAN (1-897): 1.24e-171: 524: 40.41		DDX41_HUMAN (18-394): 1.19e-47: 178: 30.95
+	Hs
		903549 WDR5_HUMAN (546-909): 5.2e-38: 147: 7.95		DDX18_HUMAN (6-467): 8.02e-159: 472: 29.61
+	Sc
		416039 COPA_YEAST (1-447): 1.7e-49: 192: 12.05		DED1_YEAST (3-402): 8.68e-139: 418: 25.55
+	Hs
		903327 WDR5_HUMAN (546-909): 5.2e-38: 147: 7.95		DDX46_HUMAN (2-597): 8.55e-134: 418: 21.15
+	Sc
		976892 UTP12_YEAST (1-122): 1.57e-21: 103: 15.20		HAS1_YEAST (6-467): 1.01e-156: 460: 30.98
+	Hs
		1288337 SNR40_HUMAN (143-502): 1.03e-16: 84.7: 22.28		DDX18_HUMAN (6-467): 8.02e-159: 472: 29.61
+	Hs
		903410 WDR5_HUMAN (546-909): 5.2e-38: 147: 7.95		DDX17_HUMAN (2-463): 7.88e-127: 391: 21.89
+	Hs
		571382 WDR5_HUMAN (546-909): 5.2e-38: 147: 7.95		DDX5_HUMAN (2-454): 2.38e-125: 384: 22.34
+	Hs
		133956 WDR5_HUMAN (546-909): 5.2e-38: 147: 7.95		DDX3X_HUMAN (4-406): 1.31e-116: 363: 24.40
+	Hs
		1271621 SNR40_HUMAN (143-502): 1.03e-16: 84.7: 22.28		DDX17_HUMAN (2-463): 7.88e-127: 391: 21.89
+	Hs
		571547 SNR40_HUMAN (143-502): 1.03e-16: 84.7: 22.28		DDX5_HUMAN (2-454): 2.38e-125: 384: 22.34
+	Hs
		1271679 NLE1_HUMAN (669-882): 5.38e-12: 71: 11.66		DDX17_HUMAN (2-463): 7.88e-127: 391: 21.89
+	Hs
		903507 WDR5_HUMAN (546-909): 5.2e-38: 147: 7.95		DDX47_HUMAN (23-382): 7.93e-54: 191: 34.35
+	Sc
		593727 UTP12_YEAST (1-122): 1.57e-21: 103: 15.20		DBP4_YEAST (21-467): 7e-51: 189: 31.36
+	Hs
		1288370 SNR40_HUMAN (143-502): 1.03e-16: 84.7: 22.28		DDX41_HUMAN (18-394): 1.19e-47: 178: 30.95
+	Hs
		921718 GBB2_HUMAN (342-550): 1.77e-09: 62.4: 21.46		DDX47_HUMAN (23-382): 7.93e-54: 191: 34.35