HitPredict

Interactor 1: PWP2 (P25635)
Periodic tryptophan protein 2 (U three protein 1) (U3 small nucleolar RNA-associated protein 1) (U3 snoRNA-associated protein 1)
Gene: PWP2

Interactor 2: UTP5 (Q04177)
U3 small nucleolar RNA-associated protein 5 (U3 snoRNA-associated protein 5) (U three protein 5) (U3 protein 5 required for transcription) (t-UTP5)
Gene: UTP5

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	29263326, 35650250, 37968396
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Utp12~Utp12
Common GO terms	GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0005654 - nucleoplasm GO:0005730 - nucleolus GO:0030490 - maturation of SSU-rRNA GO:0032040 - small-subunit processome
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 923 Sc			1 643
+	Sc
		635548 PWP2_YEAST (1-923): 0: 650: 100.00		PWP2_YEAST (66-382): 8.9e-29: 124: 11.45
+	Hs
		1070055 PWP2_HUMAN (1-897): 1.24e-171: 524: 40.41		WDR3_HUMAN (212-428): 2.31e-19: 94.8: 12.56
+	Hs
		1016312 TBL3_HUMAN (79-849): 6.24e-108: 354: 13.69		SNR40_HUMAN (90-395): 4.79e-57: 198: 8.68
+	Hs
		903174 TBL3_HUMAN (79-849): 6.24e-108: 354: 13.69		WDR5_HUMAN (222-436): 1.33e-20: 95.2: 9.69
+	Hs
		1016345 TBL3_HUMAN (79-849): 6.24e-108: 354: 13.69		WDR3_HUMAN (212-428): 2.31e-19: 94.8: 12.56
+	Hs
		1016282 TBL3_HUMAN (79-849): 6.24e-108: 354: 13.69		PWP2_HUMAN (151-463): 2.89e-09: 62.4: 7.83
+	Hs
		1288390 WDR3_HUMAN (1-255): 3.01e-41: 165: 15.93		SNR40_HUMAN (90-395): 4.79e-57: 198: 8.68
+	Hs
		903428 WDR5_HUMAN (546-909): 5.2e-38: 147: 7.95		SNR40_HUMAN (90-395): 4.79e-57: 198: 8.68
+	Hs
		792949 WDR5_HUMAN (546-909): 5.2e-38: 147: 7.95		LIS1_HUMAN (2-218): 1.53e-48: 176: 10.04
+	Sc
		744660 COPA_YEAST (1-447): 1.7e-49: 192: 12.05		TAF5_YEAST (5-290): 8.72e-27: 118: 13.15
+	Hs
		1309163 TBL1R_HUMAN (19-222): 1.04e-26: 117: 17.21		TBL1Y_HUMAN (89-382): 9.04e-46: 171: 8.10
+	Hs
		196984 WDR5_HUMAN (546-909): 5.2e-38: 147: 7.95		PRP4_HUMAN (174-423): 2e-22: 103: 7.72
+	Hs
		245633 TBL1R_HUMAN (19-222): 1.04e-26: 117: 17.21		TBL1X_HUMAN (131-398): 3.35e-30: 127: 8.39
+	Hs
		903077 WDR5_HUMAN (546-909): 5.2e-38: 147: 7.95		WDR5_HUMAN (222-436): 1.33e-20: 95.2: 9.69
+	Hs
		903349 WDR5_HUMAN (546-909): 5.2e-38: 147: 7.95		WDR5B_HUMAN (222-423): 7.65e-20: 92.9: 9.81
+	Hs
		863397 COPA_HUMAN (2-394): 3.56e-29: 128: 9.05		WDR5_HUMAN (222-436): 1.33e-20: 95.2: 9.69
+	Hs
		903605 WDR5_HUMAN (546-909): 5.2e-38: 147: 7.95		PRP19_HUMAN (135-289): 4.7e-11: 67.7: 15.19
+	Sp
		140390 TAF5_SCHPO (256-503): 2.12e-22: 105: 26.05		TAF73_SCHPO (4-217): 3.48e-23: 106: 13.89