HitPredict

Interactor 1: DNJB1 (P25685)
DnaJ homolog subfamily B member 1 (DnaJ protein homolog 1) (Heat shock 40 kDa protein 1) (HSP40) (Heat shock protein 40) (Human DnaJ protein 1) (hDj-1)
Gene: DNAJB1

Interactor 2: HSP74 (P34932)
Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2)
Gene: HSPA4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.902

Property	Details
Experiments	27708256, 14503850, 33957083, 35271311
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	DnaJ~HSP70
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0006986 - response to unfolded protein GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 340 Hs			1 840
+	Hs
		714449 DNJB4_HUMAN (1-339): 1.15e-134: 388: 64.60		HSP74_HUMAN (1-840): 0: 993: 100.00
+	Hs
		279281 DNJB5_HUMAN (1-339): 3.31e-126: 366: 59.71		HSP74_HUMAN (1-840): 0: 993: 100.00
+	Hs
		320814 DNJB1_HUMAN (1-340): 5.05e-137: 394: 100.00		HS74L_HUMAN (1-840): 0: 959: 63.21
+	Hs
		636386 DNJB1_HUMAN (1-340): 5.05e-137: 394: 100.00		HS105_HUMAN (1-840): 0: 938: 62.95
+	Hs
		1267773 DNJB4_HUMAN (1-339): 1.15e-134: 388: 64.60		HS105_HUMAN (1-840): 0: 938: 62.95
+	Hs
		1123860 Q59E89_HUMAN (1-339): 2.98e-132: 382: 64.31		HS105_HUMAN (1-840): 0: 938: 62.95
+	Hs
		279330 DNJB5_HUMAN (1-339): 3.31e-126: 366: 59.71		HS105_HUMAN (1-840): 0: 938: 62.95
+	Dm
		1096122 DNAJ1_DROME (1-339): 2.7e-118: 346: 51.32		Q9VUC1_DROME (1-840): 0: 821: 42.10
+	Hs
		503463 DNJB1_HUMAN (1-340): 5.05e-137: 394: 100.00		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		483773 DNJB1_HUMAN (1-340): 5.05e-137: 394: 100.00		HS71B_HUMAN (571-686): 1.59e-19: 95.5: 23.93
+	Hs
		636256 DNJB1_HUMAN (1-340): 5.05e-137: 394: 100.00		HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48
+	Hs
		504901 DNJB4_HUMAN (1-339): 1.15e-134: 388: 64.60		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		483809 DNJB4_HUMAN (1-339): 1.15e-134: 388: 64.60		HS71B_HUMAN (571-686): 1.59e-19: 95.5: 23.93
+	Hs
		714088 DNJB4_HUMAN (1-339): 1.15e-134: 388: 64.60		HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48
+	Hs
		564008 DNJB1_HUMAN (1-340): 5.05e-137: 394: 100.00		HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86
+	Hs
		564203 DNJB4_HUMAN (1-339): 1.15e-134: 388: 64.60		HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86
+	Hs
		279272 DNJB5_HUMAN (1-339): 3.31e-126: 366: 59.71		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		279280 DNJB5_HUMAN (1-339): 3.31e-126: 366: 59.71		HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48
+	Hs
		279274 DNJB5_HUMAN (1-339): 3.31e-126: 366: 59.71		HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86
+	Hs
		483775 DNJA1_HUMAN (5-339): 2.97e-117: 346: 32.77		HS71B_HUMAN (571-686): 1.59e-19: 95.5: 23.93