HitPredict

Interactor 1: PSA2 (P25787)
Proteasome subunit alpha type-2 (Macropain subunit C3) (Multicatalytic endopeptidase complex subunit C3) (Proteasome component C3)
Gene: PSMA2

Interactor 2: UBE3C (Q15386)
Ubiquitin-protein ligase E3C (EC 2.3.2.26) (HECT-type ubiquitin transferase E3C) (Homologous to E6AP carboxyl terminus homologous protein 2) (HectH2) (RTA-associated ubiquitin ligase) (RAUL)
Gene: UBE3C

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	19193609
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 234 Hs			1 1083
+	Hs
		656235 PSA5_HUMAN (1-233): 2.69e-97: 285: 30.96		UBE3C_HUMAN (1-1083): 0: 1136: 100.00
+	Hs
		893675 PSA6_HUMAN (2-234): 2.68e-90: 267: 34.73		UBE3C_HUMAN (1-1083): 0: 1136: 100.00
+	Hs
		637427 PSA1_HUMAN (1-233): 1.31e-89: 266: 30.67		UBE3C_HUMAN (1-1083): 0: 1136: 100.00
+	Hs
		156366 PSA7_HUMAN (6-231): 1.49e-89: 266: 36.52		HECW2_HUMAN (262-1082): 0: 591: 19.91
+	Hs
		637675 PSA2_HUMAN (1-234): 2.95e-97: 285: 100.00		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		656207 PSA5_HUMAN (1-233): 2.69e-97: 285: 30.96		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		656320 PSA5_HUMAN (1-233): 2.69e-97: 285: 30.96		SMUF1_HUMAN (562-1080): 3.14e-177: 539: 22.78
+	Hs
		893654 PSA6_HUMAN (2-234): 2.68e-90: 267: 34.73		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		156275 PSA7_HUMAN (6-231): 1.49e-89: 266: 36.52		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		637394 PSA1_HUMAN (1-233): 1.31e-89: 266: 30.67		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		638114 PSA4_HUMAN (4-211): 1.24e-42: 146: 38.68		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Sc
		619495 PSA2_YEAST (1-233): 4.51e-84: 252: 56.97		HUL5_YEAST (662-1083): 8.08e-75: 268: 39.07
+	Hs
		637712 PSA2_HUMAN (1-234): 2.95e-97: 285: 100.00		HUWE1_HUMAN (683-1083): 1.53e-47: 188: 32.60
+	Hs
		656264 PSA5_HUMAN (1-233): 2.69e-97: 285: 30.96		HUWE1_HUMAN (683-1083): 1.53e-47: 188: 32.60
+	Hs
		893701 PSA6_HUMAN (2-234): 2.68e-90: 267: 34.73		HUWE1_HUMAN (683-1083): 1.53e-47: 188: 32.60
+	Hs
		156320 PSA7_HUMAN (6-231): 1.49e-89: 266: 36.52		HUWE1_HUMAN (683-1083): 1.53e-47: 188: 32.60
+	Hs
		637468 PSA1_HUMAN (1-233): 1.31e-89: 266: 30.67		HUWE1_HUMAN (683-1083): 1.53e-47: 188: 32.60
+	Sc
		619506 PSA2_YEAST (1-233): 4.51e-84: 252: 56.97		TOM1_YEAST (683-1083): 1.4e-46: 185: 32.12
+	Sc
		619384 PSA3_YEAST (1-230): 8.97e-46: 154: 36.40		TOM1_YEAST (683-1083): 1.4e-46: 185: 32.12
+	Hs
		638160 PSA4_HUMAN (4-211): 1.24e-42: 146: 38.68		HUWE1_HUMAN (683-1083): 1.53e-47: 188: 32.60