HitPredict

Interactor 1: PSA3 (P25788)
Proteasome subunit alpha type-3 (Macropain subunit C8) (Multicatalytic endopeptidase complex subunit C8) (Proteasome component C8)
Gene: PSMA3

Interactor 2: PRS6B (P43686)
26S proteasome regulatory subunit 6B (26S proteasome AAA-ATPase subunit RPT3) (MB67-interacting protein) (MIP224) (Proteasome 26S subunit ATPase 4) (Tat-binding protein 7) (TBP-7)
Gene: PSMC4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	22079093, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	AAA~Proteasome, AAA_lid_3~Proteasome, AAA~Proteasome_A_N, AAA_lid_3~Proteasome_A_N
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process and 1 others more... GO:0045202 - synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 255 Hs			1 418
+	Dm
		1359403 PSA3_DROME (1-252): 1.3e-108: 315: 57.54		Q9V405_DROME (4-418): 6.87e-131: 384: 86.27
+	Sc
		597220 PSA7_YEAST (1-246): 4.1e-111: 322: 51.20		PRS6B_YEAST (1-418): 7.52e-127: 374: 66.82
+	At
		286460 PSA5A_ARATH (1-239): 1e-100: 294: 31.41		PRS4A_ARATH (8-412): 1.44e-135: 397: 47.43
+	At
		1114627 PSA5B_ARATH (1-239): 3.02e-100: 293: 31.82		PRS4A_ARATH (8-412): 1.44e-135: 397: 47.43
+	Sc
		597249 PSA7_YEAST (1-246): 4.1e-111: 322: 51.20		PRS4_YEAST (34-414): 2.92e-124: 368: 50.38
+	At
		286458 PSA4A_ARATH (4-249): 9.98e-100: 292: 32.80		PRS4A_ARATH (8-412): 1.44e-135: 397: 47.43
+	Hs
		656167 PSA5_HUMAN (1-239): 4.52e-96: 283: 31.97		PRS6B_HUMAN (1-418): 3.22e-139: 406: 100.00
+	Dm
		186137 PSA3_DROME (1-252): 1.3e-108: 315: 57.54		PRS8_DROME (38-418): 1.01e-125: 371: 41.73
+	At
		188712 PSA3_ARATH (1-250): 6.76e-97: 285: 60.40		PRS4A_ARATH (8-412): 1.44e-135: 397: 47.43
+	Dm
		1360094 PSA3_DROME (1-252): 1.3e-108: 315: 57.54		Q9W414_DROME (28-417): 9.19e-124: 366: 41.94
+	Sc
		597258 PSA7_YEAST (1-246): 4.1e-111: 322: 51.20		PRS10_YEAST (12-418): 2.63e-120: 358: 40.34
+	Ce
		184349 PSA3_CAEEL (1-251): 2.1e-108: 314: 49.00		PRS10_CAEEL (18-417): 1.85e-122: 362: 39.00
+	Dm
		820506 PSA3_DROME (1-252): 1.3e-108: 315: 57.54		PRS4_DROME (7-412): 3.89e-120: 358: 45.59
+	Dm
		1278638 PSA5_DROME (1-240): 1.81e-96: 284: 27.94		Q9V405_DROME (4-418): 6.87e-131: 384: 86.27
+	Hs
		637839 PSA3_HUMAN (1-255): 5.2e-97: 285: 100.00		PRS10_HUMAN (35-417): 3.49e-126: 371: 40.47
+	Dm
		186129 PSA5_DROME (1-240): 1.81e-96: 284: 27.94		PRS8_DROME (38-418): 1.01e-125: 371: 41.73
+	Dm
		1278655 PSA5_DROME (1-240): 1.81e-96: 284: 27.94		Q9W414_DROME (28-417): 9.19e-124: 366: 41.94
+	Hs
		637836 PSA3_HUMAN (1-255): 5.2e-97: 285: 100.00		PRS8_HUMAN (38-418): 1.7e-122: 362: 42.26
+	Hs
		637835 PSA3_HUMAN (1-255): 5.2e-97: 285: 100.00		PRS4_HUMAN (32-412): 2.96e-120: 358: 49.09
+	Dm
		820495 PSA5_DROME (1-240): 1.81e-96: 284: 27.94		PRS4_DROME (7-412): 3.89e-120: 358: 45.59