HitPredict

Interactor 1: PSA3 (P25788)
Proteasome subunit alpha type-3 (Macropain subunit C8) (Multicatalytic endopeptidase complex subunit C8) (Proteasome component C8)
Gene: PSMA3

Interactor 2: PRS4 (P62191)
26S proteasome regulatory subunit 4 (P26s4) (26S proteasome AAA-ATPase subunit RPT2) (Proteasome 26S subunit ATPase 1)
Gene: PSMC1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	35235311, 15837734
Identification Methods	cross-linking study, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AAA~Proteasome, AAA_lid_3~Proteasome, AAA~Proteasome_A_N, AAA_lid_3~Proteasome_A_N
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 255 Hs			1 440
+	Dm
		820506 PSA3_DROME (1-252): 1.3e-108: 315: 57.54		PRS4_DROME (1-440): 1.71e-137: 403: 91.36
+	Sc
		597249 PSA7_YEAST (1-246): 4.1e-111: 322: 51.20		PRS4_YEAST (1-440): 2.21e-129: 382: 71.36
+	At
		286460 PSA5A_ARATH (1-239): 1e-100: 294: 31.41		PRS4A_ARATH (1-440): 1.58e-135: 398: 76.30
+	At
		1114627 PSA5B_ARATH (1-239): 3.02e-100: 293: 31.82		PRS4A_ARATH (1-440): 1.58e-135: 398: 76.30
+	Dm
		186137 PSA3_DROME (1-252): 1.3e-108: 315: 57.54		PRS8_DROME (57-433): 1.81e-127: 376: 46.95
+	At
		286458 PSA4A_ARATH (4-249): 9.98e-100: 292: 32.80		PRS4A_ARATH (1-440): 1.58e-135: 398: 76.30
+	Dm
		820495 PSA5_DROME (1-240): 1.81e-96: 284: 27.94		PRS4_DROME (1-440): 1.71e-137: 403: 91.36
+	Sc
		597263 PSA7_YEAST (1-246): 4.1e-111: 322: 51.20		PRS8_YEAST (42-432): 3.07e-122: 363: 44.50
+	Dm
		1360094 PSA3_DROME (1-252): 1.3e-108: 315: 57.54		Q9W414_DROME (54-438): 8.04e-125: 369: 40.52
+	At
		188712 PSA3_ARATH (1-250): 6.76e-97: 285: 60.40		PRS4A_ARATH (1-440): 1.58e-135: 398: 76.30
+	Dm
		1359403 PSA3_DROME (1-252): 1.3e-108: 315: 57.54		Q9V405_DROME (35-433): 1.14e-123: 367: 47.87
+	Sc
		597220 PSA7_YEAST (1-246): 4.1e-111: 322: 51.20		PRS6B_YEAST (60-422): 1.52e-118: 354: 50.28
+	Dm
		186129 PSA5_DROME (1-240): 1.81e-96: 284: 27.94		PRS8_DROME (57-433): 1.81e-127: 376: 46.95
+	Hs
		637839 PSA3_HUMAN (1-255): 5.2e-97: 285: 100.00		PRS10_HUMAN (66-438): 7.99e-126: 371: 40.75
+	Dm
		1278655 PSA5_DROME (1-240): 1.81e-96: 284: 27.94		Q9W414_DROME (54-438): 8.04e-125: 369: 40.52
+	Dm
		1278638 PSA5_DROME (1-240): 1.81e-96: 284: 27.94		Q9V405_DROME (35-433): 1.14e-123: 367: 47.87
+	Hs
		637836 PSA3_HUMAN (1-255): 5.2e-97: 285: 100.00		PRS8_HUMAN (55-433): 1.06e-123: 366: 46.70
+	Dm
		1359221 PSA3_DROME (1-252): 1.3e-108: 315: 57.54		Q9V3V6_DROME (73-431): 3.12e-111: 335: 46.70
+	Hs
		637801 PSA3_HUMAN (1-255): 5.2e-97: 285: 100.00		PRS6B_HUMAN (50-433): 1.06e-122: 364: 48.96
+	Dm
		1278637 PSA5_DROME (1-240): 1.81e-96: 284: 27.94		Q9V3V6_DROME (73-431): 3.12e-111: 335: 46.70