HitPredict

Interactor 1: PSA4 (P25789)
Proteasome subunit alpha type-4 (Macropain subunit C9) (Multicatalytic endopeptidase complex subunit C9) (Proteasome component C9) (Proteasome subunit L)
Gene: PSMA4

Interactor 2: PSME4 (Q14997)
Proteasome activator complex subunit 4 (Proteasome activator PA200)
Gene: PSME4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	35271311, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	BLM10_mid~Proteasome, DUF3437~Proteasome, BLM10_mid~Proteasome_A_N, DUF3437~Proteasome_A_N
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 261 Hs			1 1843
+	Hs
		108944 H0YKT8_HUMAN (25-205): 1.07e-132: 374: 100.00		PSME4_HUMAN (1-1843): 0: 2463: 100.00
+	Hs
		893671 PSA6_HUMAN (2-244): 3.23e-92: 273: 31.84		PSME4_HUMAN (1-1843): 0: 2463: 100.00
+	Hs
		637420 PSA1_HUMAN (4-259): 2.5e-91: 272: 28.57		PSME4_HUMAN (1-1843): 0: 2463: 100.00
+	Hs
		156290 PSA7_HUMAN (5-238): 2.84e-91: 271: 33.19		PSME4_HUMAN (1-1843): 0: 2463: 100.00
+	Hs
		637689 PSA2_HUMAN (3-214): 6.04e-42: 145: 38.68		PSME4_HUMAN (1-1843): 0: 2463: 100.00
+	Sc
		619369 PSA3_YEAST (2-245): 2.67e-89: 267: 52.03		BLM10_YEAST (74-831): 0: 722: 16.61
+	Sc
		771369 PSA4_YEAST (3-240): 1.72e-87: 262: 32.37		BLM10_YEAST (74-831): 0: 722: 16.61
+	Sc
		619483 PSA2_YEAST (1-220): 3.05e-39: 138: 38.01		BLM10_YEAST (74-831): 0: 722: 16.61