HitPredict

Interactor 1: SPB4 (P25808)
ATP-dependent rRNA helicase SPB4 (EC 3.6.4.13) (Suppressor of PAB1 protein 4)
Gene: SPB4

Interactor 2: NOP15 (P53927)
Ribosome biogenesis protein 15 (Nucleolar protein 15)
Gene: NOP15

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.91	0.60	0.740

Property	Details
Experiments	17922018, 16429126, 30568249, 36929751, 37968396, 37811893, 21825077
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005730 - nucleolus GO:0030687 - preribosome, large subunit precursor
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 606 Sc			1 220
+	Sc
		866255 HAS1_YEAST (6-467): 1.01e-156: 460: 30.98		NOP15_YEAST (1-220): 1.29e-46: 155: 100.00
+	Hs
		1316910 DDX18_HUMAN (6-467): 8.02e-159: 472: 29.61		MK67I_HUMAN (60-220): 8.1e-40: 139: 28.73
+	Dm
		1363283 DDX18_DROME (6-481): 1.03e-152: 457: 28.96		Q9VCY1_DROME (72-204): 1.41e-38: 138: 29.20
+	Hs
		571585 DDX5_HUMAN (2-454): 2.38e-125: 384: 22.34		MK67I_HUMAN (60-220): 8.1e-40: 139: 28.73
+	Hs
		198838 DDX5_HUMAN (2-454): 2.38e-125: 384: 22.34		RFOX2_HUMAN (19-183): 1.37e-35: 131: 19.88
+	Hs
		1245873 DDX55_HUMAN (6-594): 5.25e-122: 375: 34.05		MK67I_HUMAN (60-220): 8.1e-40: 139: 28.73
+	Hs
		1183370 DDX46_HUMAN (2-597): 8.55e-134: 418: 21.15		PUF60_HUMAN (11-173): 8.5e-21: 91.8: 20.83
+	Hs
		1073611 DDX17_HUMAN (2-463): 7.88e-127: 391: 21.89		SF3B4_HUMAN (79-209): 1.67e-27: 109: 19.85
+	Hs
		1077436 DDX17_HUMAN (2-463): 7.88e-127: 391: 21.89		ELAV1_HUMAN (85-207): 6.15e-25: 101: 18.70
+	Hs
		571469 DDX5_HUMAN (2-454): 2.38e-125: 384: 22.34		ELAV1_HUMAN (85-207): 6.15e-25: 101: 18.70
+	Mm
		857323 DDX17_MOUSE (2-435): 4.12e-126: 387: 22.83		TIA1_MOUSE (86-216): 1.37e-21: 93.1: 18.80
+	Mm
		857351 Q8BTS0_MOUSE (2-454): 7.2e-126: 385: 22.34		TIA1_MOUSE (86-216): 1.37e-21: 93.1: 18.80
+	Mm
		936480 DDX5_MOUSE (2-454): 1.28e-126: 387: 22.34		TIAR_MOUSE (85-207): 1.08e-20: 90.8: 15.94
+	Hs
		133858 DDX3X_HUMAN (4-406): 1.31e-116: 363: 24.40		PABP1_HUMAN (82-207): 1.24e-25: 105: 15.87
+	Hs
		134018 DDX3X_HUMAN (4-406): 1.31e-116: 363: 24.40		PABP4_HUMAN (89-207): 3.83e-25: 104: 17.65
+	Hs
		134244 DDX3X_HUMAN (4-406): 1.31e-116: 363: 24.40		PUF60_HUMAN (11-173): 8.5e-21: 91.8: 20.83
+	Sc
		699710 DRS1_YEAST (21-392): 3.9e-47: 178: 31.75		NOP15_YEAST (1-220): 1.29e-46: 155: 100.00
+	Hs
		1027929 DDX10_HUMAN (21-472): 5.23e-47: 179: 29.67		MK67I_HUMAN (60-220): 8.1e-40: 139: 28.73